唾液生物标志物在阿尔茨海默病早期检测中的应用  

Application of Saliva Biomarkers in Early Detection of Alzheimer's Disease.

作　　者：马国武[1] 赵鹏程 MA Guowu;ZHAO Pengcheng(School of Stomatology, Dalian Medical University, Dalian 116000, China.)

机构地区：[1]大连医科大学口腔医学院,辽宁大连116000

出　　处：《口腔医学研究》2022年第7期591-596,共6页Journal of Oral Science Research

基　　金：国家自然基金面上项目(编号:62171077)。

摘　　要：唾液中包含多种生物标志物,与口腔及全身疾病的发生、发展及诊疗监控密切相关。生物标志物的检测在阿尔茨海默病(Alzheimer's disease,AD)的早期筛查和诊断中具有重要意义,唾液因其与神经系统的紧密联系有望成为AD相关生物标志物的取材库。本文对唾液中AD相关生物标志物及其检测用生物传感器进行介绍和评估,以期为AD唾液生物标志物及非侵入式生物传感器的开发和应用提供新思路。Saliva contains many biomarkers,which are closely related to the occurrence,development,diagnosis,and treatment of oral and systemic diseases.The detection of biomarkers plays an important role in the early screening and diagnosis of Alzheimer's disease(AD).Because of its close connection with the nervous system,saliva is expected to become a library of AD-related biomarkers.This article introduces and evaluates the biomarkers in saliva that can be used for early detection of AD and the biosensors that can be used to detect these markers,in order to provide new ideas for the development of reliable AD saliva biomarkers and non-invasive biosensors.

关 键 词：阿尔茨海默病 生物标志物 生物传感器 唾液 

分 类 号：R749.16[医药卫生—神经病学与精神病学]