Response to lipopolysaccharide in Octodon degus pups produces age-related sickness behavior but does not have effects in juveniles  

作　　者：Natalia RAMIREZ-OTAROLA Janyra ESPINOZA Alexis M.KALERGIS Pablo SABAT 

机构地区：[1]Department of Ecological Sciences,Science Faculty,Universidad de Chile,Santiago,Chile [2]Millennium Institute Immunology and Immunotherapy,Departamento de Genética Molecular y Microbiología,Facultad de Ciencias Biológicas,Pontificia Universidad Católica de Chile,Santiago,Chile [3]Departamento de Endocrinología,Facultad de Medicina,Pontificia Universidad Católica de Chile,Santiago,Chile [4]Department of Ecology,Center of Applied Ecology&Sustainability,Biological Sciences Faculty,Pontificia Universidad Católica de Chile,Santiago,Chile

出　　处：《Integrative Zoology》2019年第3期235-247,共13页整合动物学（英文版）

基　　金：This study was funded by FONDECYT 3160133 to NRO and Millennium Institute of Immunology and Immunotherapy,Pontificia Univer­sidad Católica de Chile。

摘　　要：During vertebrate development,the immune function is inefficient and is mainly controlled by innate defense.While there have been detailed studies of various aspects of innate immune function,the effects of this func­tion in the growth of vertebrates is still not well known.Similarly,there is little information regarding how ear­ly endotoxin exposure would affect juvenile phenotypes,specifically in a non-model mammal like a precocial rodent.We evaluated the response to an antigen and its cost in offspring of the rodent Octodon degus.We in­oculated pups at 4 different ages(8,15,22 and 30 days after birth)with an antigen to determine the ontogeny and costs of the response to an endotoxin.We assessed changes in body mass,body temperature,sickness be­havior and the levels of a key mediator of the inflammatory response,the cytokine interleukin-1β.We also de­termined the effects of early endotoxin exposure on the resting metabolic rate of juvenile animals(i.e.90 days after birth).The cytokine levels,body mass and body temperature were unaffected by time of inoculation and treatment.However,pups subjected to inoculation at 22 days after birth with the antigen showed reduced loco­motion.Juvenile resting metabolic rate was not affected by early endotoxin exposure.These results suggest that the magnitude of O.degus responses would not change with age.We discuss whether the lack of effect of the response on body mass or body condition is caused by environmental variables or by the precocial characteris­tics of O.degus.

关 键 词：acute phase response ecoimmunology LIPOPOLYSACCHARIDE PRECOCIAL sickness behavior 

分 类 号：R57[医药卫生—消化系统]