药物性牙龈肥大发病机制的研究进展  

Advances in studies on pathogenesis of drug-induced gingival overgrowth

作　　者：李佩桐 王双成 刘桢 王骏 LI Peitong;WANG Shuangcheng;LIU Zhen;WANG Jun(State Key Laboratory of Oral Diseases&Naional Clinical Research Center for Oral Diseases&West China School of Stomatology,Sichuan Universily,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医学院,四川成都610041 [2]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周病科,四川成都610041

出　　处：《口腔医学》2022年第6期545-550,共6页Stomatology

基　　金：国家自然科学基金面上项目(82071127);四川省卫生健康委医学科技项目(21PJ061);四川大学华西口腔医院人才队伍建设科研经费资助项目(RCDWJS2020-12)。

摘　　要：药物性牙龈肥大(DIGO)主要由长期服用苯妥英钠、环孢素A、硝苯地平引起,不仅影响牙面的清洁与美观和牙齿正常生理功能,而且可能造成患者心理上的障碍。然而,DIGO发病机制复杂,无法明确,导致治疗较为棘手。许多学者对其进行了多方面的研究,提出许多观点与假设,包括胶原生成与降解失衡机制、炎症等。该文从分子机制与药物具体机制两方面总结了近几年对DIGO发病的研究,并对DIGO未来的研究方向进行探讨,希望能够对DIGO的预防与临床治疗有所帮助。Drug-induced gingival overgrowth(DIGO)is mainly caused by long-term use of phenytoin sodium,cyclosporine A,and nifedipine.It not only affects the cleanliness and aesthetics of dental surface and the normal physiological function of teeth,but may also cause psychological disorders in patients.However,the pathogenesis of DIGO is complex and remains unclear,making treatment more difficult.Many scholars have studied it from various aspects and put forward many ideas and hypotheses,including the mechanism of collagen production and degradation imbalance,inflammation and so on.This article summarizes research on the pathogenesis of DIGO in recent years from aspects of both molecular mechanism and specific mechanism of drugs,and discusses the future research direction of DIGO,hoping to help the prevention and clinical treatment of DIGO.

关 键 词：药物性牙龈增生 胶原 炎症 苯妥英钠 环孢素A 硝苯地平 

分 类 号：R781.4[医药卫生—口腔医学]