脂质代谢在乳腺癌发病中的作用  

The Progress of Lipid Metabolism in Breast Cancer

作　　者：王淼[1] 王欣宇 李鸿铭 张红胜[1] WANG Miao;WANG Xin-Yu;LI Hong-Ming;ZHANG Hong-Sheng(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《生物化学与生物物理进展》2022年第6期1052-1060,共9页Progress In Biochemistry and Biophysics

基　　金：北京市自然科学基金(7192014);中国科学院基因组学与精准医学重点实验室开放项目(201901);北京工业大学研究生课程思政示范项目(2021010)资助。

摘　　要：乳腺癌已经成为全球第一大癌症,其发病机制及治疗方法的探索越来越受到人们重视。脂质代谢异常是癌细胞中最突出的代谢改变之一,探索乳腺癌细胞中脂质代谢的改变,以寻找新的诊断指标和治疗靶点是至关重要的。本文从脂肪酸代谢、甘油三酯代谢、胆固醇代谢和脂质代谢信号通路4个方面介绍脂质代谢异常在乳腺癌中的研究进展,为靶向脂质代谢治疗乳腺癌提供新思路和新方法。Breast cancer has become the first rank cancer in the world,and the exploration of the pathogenesis and treatment of breast cancer deserves more and more attention.Lipid metabolism dysfunction is one of the most prominent metabolic changes in cancer cells.It is very important to explore the changes of lipid metabolism in breast cancer cells in order to find new diagnostic indicators and therapeutic targets.This paper introduces the research progress of lipid metabolism dysfunction in breast cancer from 4 aspects:(1)the expression of abnormal fatty acid metabolism in breast cancer from three aspects of fatty acid synthesis,oxidation and uptake and the related research progress;(2)introduction to the abnormal expression of triglyceride metabolism in breast cancer from the aspects of triglyceride synthesis and degradation and the related research progress;(3)to introduce the abnormal expression of cholesterol synthase in breast cancer and the related research progress;(4)to introduce the abnormal expression of lipid metabolism signaling pathways in breast cancer from five signaling pathways,namely Notch,Hippo,Hedgehog,Wnt and mTOR,and the related research progress.The aim is to provide new ideas and methods for targeting lipid metabolism in the treatment of breast cancer.

关 键 词：脂质代谢 乳腺癌 脂肪酸代谢 甘油三酯代谢 胆固醇代谢 

分 类 号：R73[医药卫生—肿瘤] Q54[医药卫生—临床医学]