血清TAM、TAP联合检测在食管癌诊断及恶性程度评估中的应用研究  

Value of combined detection of serum TAM and TAP in diagnosis of esophageal cancer and evaluation on the degree of malignancy

作　　者：张新华 李小兵 吴俊鹏[1] 王虎[1] Zhang Xinhua;Li Xiaobing;Wu Junpeng;Wang Hu(Department of Thoracic Medicine,Anyang Tumor Hospital Affiliated to Henan University of Science and Technology,Anyang 455000,China)

机构地区：[1]河南科技大学附属安阳市肿瘤医院胸一科,安阳455000

出　　处：《中国实用医刊》2022年第8期34-37,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清肿瘤相关物质(TAM)、肿瘤异常蛋白(TAP)联合检测在食管癌诊断及恶性程度评估中的应用价值。方法抽取河南科技大学附属安阳市肿瘤医院2020年6月至2021年6月收治的食管癌患者82例作为观察组,抽取医院同期健康体检者50例作为对照组,检测两组血清TAM、TAP水平。82例食管癌患者中TNM分期Ⅰ期14例,Ⅱ期31例,Ⅲ期28例,Ⅳ期9例,比较不同TNM分期食管癌患者的血清TAM、TAP水平。分析两种指标联合检测对食管癌诊断及恶性程度评估的价值。结果观察组血清TAM水平为(103.96±16.21)U/ml,TAP水平为(131.85±21.73)μm^(2),高于对照组的(82.37±7.35)U/ml、(70.26±11.91)μm^(2),P<0.05;血清TAM、TAP联合检测诊断食管癌的灵敏度最高(P<0.05);随肿瘤分期严重程度加剧,食管癌患者血清TAM、TAP水平升高(P<0.05);Ⅲ期和Ⅳ期患者血清TAM、TAP水平高于Ⅰ期和Ⅱ期患者(P<0.05);经Spearman相关分析显示,食管癌患者血清TAM、TAP水平与TNM分期均呈正相关(r=0.512、0.603,P均<0.05)。结论血清TAM、TAP联合检测在食管癌诊断中的应用价值较高,且可以有效评估肿瘤恶性程度,为食管癌临床诊治提供参考。Objective To investigate the value of combined detection of serum tumor associated material(TAM)and tumor abnormal protein(TAP)in the diagnosis of esophageal cancer and the evaluation on the degree of malignancy.Methods Eighty-two patients with esophageal cancer treated in Anyang Tumor Hospital Affiliated to Henan University of Science and Technology from June 2020 to June 2021 were selected as the observation group,and 50 persons who underwent physical examination during the same period in the hospital were selected as the control group.And serum TAM and TAP levels of the two groups were detected.Among 82 patients with esophageal cancer,14 patients were tumor,node and metastases(TNM)stage I,31 patients were stage II,28 patients were stage III,and 9 patients were stage IV.The serum TAM and TAP levels of patients with esophageal cancer in different TNM stages were compared.The value of the combined detection of the two indicators in the diagnosis of esophageal cancer and evaluation of malignancy degree of was analyzed.Results In the observation group,the serum TAM level was(103.96±16.21)U/ml,and the TAP level was(131.85±21.73)μm^(2),higher than the(82.37±7.35)U/ml and(70.26±11.91)μm^(2) of the control group(P<0.05).The sensitivity of combined detection of serum TAM and TAP was the highest in diagnosing esophageal cancer(P<0.05).With the aggravation of tumor stage,serum TAM and TAP levels in patients with esophageal cancer were significantly increased(P<0.05).The levels of serum TAM and TAP in patients with stageⅢandⅣwere higher than those in patients with stageⅠandⅡ(P<0.05).Results of Spearman correlation analysis showed that serum TAM and TAP levels in patients with esophageal cancer were positively correlated with TNM stage(r=0.512,0.603;all P<0.05).Conclusions The combined detection of serum TAM and TAP has high application value in the diagnosis of esophageal cancer,and can effectively evaluate the malignancy of the tumor,providing a reference for the clinical diagnosis and treatment of esophagea

关 键 词：食管癌 肿瘤相关物质 肿瘤异常蛋白 诊断 病理分级 

分 类 号：R735.1[医药卫生—肿瘤]