原发性肝癌患者介入治疗后血清IGF-1、TGF-α、CA19-9和AFP水平与复发的相关性分析  

Correlation of serum IGF-1,TGF-α,CA19-9 and AFP levels with recurrence in patients with primary hepatocellular carcinoma after interventional therapy

作　　者：王海波 樊伟 郭艳 Wang Haibo;Fan Wei;Guo Yan(Department of Interventional Radiology,Zhoukou First People’s Hospital,Zhoukou 466700,China)

机构地区：[1]河南省周口市第一人民医院放射介入科,周口466700

出　　处：《中国实用医刊》2022年第8期38-41,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨原发性肝癌患者介入治疗后血清胰岛素样生长因子1(IGF-1)、转化生长因子α(TGF-α)、癌胚抗原19-9(CA19-9)和甲胎蛋白(AFP)水平与复发的相关性。方法抽取2019年8月至2021年8月于周口市第一人民医院接受临床介入治疗的50例原发性肝癌患者作为观察组,另抽取同期50例健康体检者作为对照组。观察组患者根据介入治疗6个月后是否复发分为复发组(12例)和未复发组(38例)。对所有研究对象进行IGF-1、TGF-α、CA19-9和AFP检测。比较观察组与对照组治疗前后血清IGF-Ⅰ、TGF-α、CA19-9和AFP水平;比较观察组中复发组和未复发组介入治疗后6个月血清IGF-Ⅰ、TGF-α、CA19-9和AFP水平,分析血清IGF-Ⅰ、TGF-α、CA19-9和AFP水平的相关性。绘制血清IGF-1、TGF-α、CA19-9和AFP对原发性肝癌患者介入治疗后复发预测的受试者工作特征曲线。结果介入治疗前,对照组与观察组血清IGF-Ⅰ、TGF-α、CA19-9及AFP水平比较差异有统计学意义(P<0.05);介入治疗后,观察组血清IGF-Ⅰ、TGF-α、CA19-9及AFP水平降低,且与对照组比较差异未见统计学意义(P>0.05)。介入治疗后6个月,复发组血清IGF-Ⅰ、TGF-α、CA19-9及AFP水平均高于未复发组(P均<0.05)。IGF-1与TGF-α、CA19-9、AFP呈正相关(r=0.832、0.841、0.712,P均<0.001);TGF-α与CA19-9、AFP呈正相关(r=0.756、0.825,P均<0.001);CA19-9与AFP呈正相关(r=0.817,P<0.001)。四项指标联合预测原发性肝癌患者介入治疗后复发的曲线下面积为0.969,敏感度和特异度分别为93.78%、94.74%,均高于各指标单独预测(P<0.05)。结论监测原发性肝癌患者介入治疗后血清IGF-Ⅰ、TGF-α、CA19-9、AFP指标,能够有效帮助临床判断患者病情是否复发,同时对患者预后情况进行准确判断。Objective To investigate the correlation of serum insulin-like growth factor 1(IGF-1),transforming growth factor-α(TGF-α),cancer antigen 19-9(CA19-9)andα-fetoprotein(AFP)levels with recurrence in patients with primary hepatocellular carcinoma after interventional therapy.Methods Fifty patients with primary hepatocellular carcinoma who received interventional therapy in Zhoukou First People’s Hospital from August 2019 to August 2021 were selected as the observation group,and 50 healthy people in the same period were selected as the control group.Patients in the observation group were divided into recurrence group(12 cases)and non-recurrence group(38 cases)according to recurrence after 6 months of intervention.IGF-1,TGF-α,CA19-9 and AFP assays were performed on all study subjects.The preoperative and postoperative serum IGF-1,TGF-α,CA19-9 and AFP levels were compared between observation group and control group.And the serum IGF-1,TGF-α,CA19-9 and AFP levels were compared between recurrence group and non-recurrence group 6 months after intervention.And the correlations among the serum IGF-1,TGF-α,CA19-9 and AFP were analyzed.The receiver operating characteristic curves of serum IGF-1,TGF-α,CA19-9 and AFP for the prediction of recurrence in patients with primary hepatocellular carcinoma after interventional therapy were plotted.Results The differences in preoperative levels of serum IGF-1,TGF-α,CA19-9 and AFP between the control group and the observation group were statistically significant(P<0.05);while levels of serum IGF-1,TGF-α,CA19-9 and AFP in the observation group decreased significantly after intervention,which were not statistically different from those in the control group(P>0.05).Serum IGF-1,TGF-α,CA19-9 and AFP levels in the recurrence group were higher than those in the non-recurrence group 6 months after the intervention(all P<0.05).IGF-1 was positively correlated with TGF-α,CA19-9 and AFP(r=0.832,0.841,0.712;all P<0.001);TGF-αwas positively correlated with CA19-9 and AFP(r=0.756,0.825;al

关 键 词：原发性肝癌 介入治疗 胰岛素样生长因子1 转化生长因子-Α 癌胚抗原19-9 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]