Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis  

作　　者：Mei HUANG Zi-xi LI Juan CHEN Ling CHEN Yuan-yuan LI 

机构地区：[1]Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Laboratory Medicine,Affiliated Hospital of Chinese and Western Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [3]Department of Biochemistry and Molecular Biology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [4]School of Pharmacy,Hangzhou Medical College,Hangzhou 310053,China

出　　处：《Current Medical Science》2022年第3期483-490,共8页当代医学科学（英文）

基　　金：Health Commission of Hubei Province(No.ZY2021M014);the National Natural Science Foundation of China(No.81873725);Basic Scientific Research Funds of Department of Education of Zhejiang Province(No.KYYB202007);Zhejiang Basic Public Welfare Research Program(No.LGF22H280016);the“13th Five-Year”Chinese Medicine Key Discipline in Zhejiang Province-Chinese Medicine Quality and Functional Evaluation(No.2017-XK-A43).

摘　　要：Objective Cerebral ischemia/reperfusion(I/R)is a potential factor for lethal injury,and currently lacks effective remedies.Bauhinia championii extracts(BCEs)have been reported to exhibit anti-oxidative and anti-hypoxia properties.The current work aimed to study whether BCE could alleviate neuronal injury caused by I/R.Methods To investigate the protective effects of BCE,oxygen-glucose deprivation/reperfusion(OGD/R)was applied to the HT22 cell line in vitro and to a cerebral I/R mouse model in vivo.Results Under OGD/R,the survival of HT22 cells was significantly prolonged after treatment with BCE.In vivo,BCE significantly reduced the infarct area and decreased neuronal apoptosis caused by I/R.It was further found that OGD/R could trigger endoplasmic reticulum(ER)stress and induce ER stress-mediated neuronal apoptosis in vivo and in vitro,while BCE could effectively alleviate ER stress and neuronal apoptosis.Conclusion These results suggested that BCE exhibits neuroprotective effects by reducing ER stress-mediated apoptosis after cerebral I/R injury.BCE may therefore be an effective therapeutic regimen against cerebral I/R damage.

关 键 词：Bauhinia championii extraction ischemia/reperfusion injury endoplasmic reticulum stress neuron apoptosis 

分 类 号：R74[医药卫生—神经病学与精神病学]