丁苯酞治疗老年高危非致残性缺血性脑血管病预后因素分析  

Analysis of Prognostic Factor for Older Patients with High Risk Non-Disabling Ischemic Cerebrovascular Events Treated with Butylphthalide

作　　者：张锐利[1] 魏晓珊[2] 田志松[1] 乔志永 吴洋 Zhang Ruili;Wei Xiaoshan;Tian Zhisong;Qiao Zhiyong;Wu Yang(Department of Neurology,People’s Hospital of Zunhua,Zunhua 064200;Department of Neurology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051)

机构地区：[1]遵化市人民医院神经内科,遵化064200 [2]石家庄市中医院神经内科,石家庄050051

出　　处：《国际老年医学杂志》2022年第4期393-396,共4页International Journal of Geriatrics

基　　金：河北省2018年度医学科学研究重点课题(20181419)。

摘　　要：目的探究丁苯酞治疗的老年高危非致残性缺血性脑血管病(HR-NICE)预后因素。方法选择2017年1月~2019年7月遵化市人民医院和石家庄市中医院就诊的329例HR-NICE患者为研究对象,观察12个月患者的复发率,根据复发情况分为复发组(28例)和未复发组(301例),比较两组的临床资料,采用多因素非条件logistic回归模型分析导致患者复发的危险因素。结果多因素非条件logistic回归分析显示:中性粒细胞与淋巴细胞比值(NLR)、超敏C反应蛋白(hs-CRP)和血管狭窄是导致丁苯酞治疗老年HR-NICE复发的相关危险因素(P<0.05)。结论对于丁苯酞治疗的老年HR-NICE患者,应加强对NLR、hs-CRP水平升高和血管狭窄者的临床观察,预防复发。Objective To study the prognostic factors for older patients with high risk non-disabling ischemic cerebrovascular events(HR-NICE)treated with butylphthalide.Methods A total of 329 HR-NICE patients received treatment in People’s Hospital of Zunhua and Shijiazhuang Hospital of Traditional Chinese Medicine from January 2017 to July 2019 were enrolled,and divided into the recurrence group(28 cases)and non-recurrence group(301 cases)according to 12 months of follow-up.The clinical data of the two groups were compared,and the risk factors leading to patients’recurrence were analyzed using unconditional multivariate logistic regression model.Results As shown in the unconditional multivariate logistic regression analysis,neutrophil-to-lymphocyte ratio(NLR),high sensitivity C-reactive protein(hs-CRP)and vascular stenosis were the risk factors for recurrence of older patients with HR-NICE treated with butylphthalide(P<0.05).Conclusion For older patients with HR-NICE treated with butylphthalide,NLR,hs-CRP level and vascular stenosis should be closely monitored to prevent relapse.

关 键 词：丁苯酞 高危非致残性缺血性脑血管病 复发 中性粒细胞与淋巴细胞比值 超敏C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]