血红蛋白与红细胞分布宽度在对Ⅱ、Ⅲ期结直肠癌术后患者预后的临床分析  

Clinical Analysis of Hemoglobin-To-Red Cell Distribution Width Ratio in Patients with StageⅡandⅢColorectal Cancer

作　　者：吴冠冬 顾欣 张婷 王振欣[1] WU Guan-dong;GU Xin;ZHANG Ting;WANG Zheng-xin(Department of Oncology,First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,215006,China)

机构地区：[1]苏州大学附属第一医院肿瘤科,江苏苏州215006

出　　处：《中国血液流变学杂志》2022年第1期99-104,共6页Chinese Journal of Hemorheology

基　　金：江苏省高等学校自然科学研究重大项目(19KJA240001)。

摘　　要：目的分析术前血红蛋白与红细胞分布宽度比(HRR)对Ⅱ、Ⅲ期结直肠癌(CRC)术后患者预后的关系,评估其对预后的预测价值。方法选取2014年1月—2015年12月苏州大学附属第一医院接受根治性手术的CRC患者149例。应用χ^(2)检验、Kaplan-Meier检验、Log-rank检验、Cox风险回归模型分析患者术前HRR与预后的关系。结果所有患者中位随访时间为41个月。单因素分析发现,ECOG、体重下降、N分期、TNM分期、癌结节和HRR与无病生存期(DFS)显著相关(P<0.05),年龄、ECOG、体重下降、N分期和HRR与总生存期(OS)显著相关(P<0.05)。多因素分析显示,ECOG、体重下降和HRR是CRC术后患者DFS的独立预后危险因素,年龄、ECOG、体重下降是影响OS的重要因素。根据术前HRR水平将所有患者分为高HRR组和低HRR组,其3年DFS分别为56.1%、41.0%(P<0.01),3年OS分别为86.3%、73.4%(P<0.01)。结论术前HRR水平变化直接影响CRC患者的预后,高HRR预后较好。低HRR提示术后复发、转移风险增高,预后不佳。Objective To analyze the relationship between hemoglobin-to-red cell distribution width ratio(HRR)and prognosis of patients with stageⅡandⅢcolorectal cancer(CRC).Methods Totally 149 patients with CRC who underwent radical surgery in the First Affiliated Hospital of Soochow University,from January 2014 to December 2015 were selected.Chi-square test,Kaplan-Meier test,Log-rank test,and Cox risk regression model were used to analyze the relationships between the preoperative HRR and prognosis.Results The median follow-up time was 41 months.Univariate analysis showed that ECOG,weight loss,N stage,TNM stage,tumor nodule and HRR were the related factors affecting disease-free survival(DFS)(P<0.05),while age,ECOG,weight loss,N stage and HRR were the related factors affecting overall survival(OS)(P<0.05).Multivariate analysis showed that ECOG,weight loss and HRR were independent prognostic risk factors for DFS in patients with CRC.Age,ECOG and weight loss were important factors affecting OS.According to the preoperative HRR level,all patients were divided into high HRR group and low HRR group.The 3-year DFS was 56.1%and 41.0%respectively(P<0.01),and 3-year OS was 86.3%and 73.4%respectively(P<0.01).Conclusion The change of preoperative HRR level directly affects the prognosis of CRC patients,and the prognosis of patients with high HRR is better.Low HRR suggests an increased risk of recurrence and metastasis and a poor prognosis.

关 键 词：结直肠癌 术后 预后 血红蛋白与红细胞分布宽度比 

分 类 号：R735.35[医药卫生—肿瘤]