神经病理性疼痛的蛋白质组学研究进展  

Advances in proteomics of neuropathic pain

作　　者：郭云观 李君[1] 冯艺[1,2] GUO Yunguan;LI Jun;FENG Yi(Department of Pain Medicine,Peking University Peoples Hospital,Beijing 100044,China;Key Laboratory for Neuroscience,Ministry of Education/National Health Commission of China,Peking University,Beijing 100083,China)

机构地区：[1]北京大学人民医院疼痛医学科,北京100044 [2]神经科学教育部重点实验室/国家卫生健康委员会神经科学重点实验室,北京100083

出　　处：《中国疼痛医学杂志》2022年第6期404-410,共7页Chinese Journal of Pain Medicine

基　　金：北京市科技计划(Z181100001618007)。

摘　　要：神经病理性疼痛(neuropathic pain,NP)是常见的疼痛疾病,主要为神经系统损伤引起的疼痛。NP的诊治仍然存在难点,其病理机制也有待进一步的探索。蛋白质组学是对某一特定组织包含的全部蛋白质进行鉴定分析与定量研究的技术,广泛应用于病理机制、生物标志物、药物治疗靶点等方面的研究。本文对蛋白质组学在NP的研究现状进行综述。在基础研究方面,发现NP动物模型在代谢酶类、信号转导和氧化应激等方面的蛋白水平发生显著改变。在临床研究方面,发现带状疱疹后神经痛等疾病导致氧化应激、细胞外基质蛋白、丝裂原活化蛋白激酶信号通路等蛋白水平有显著变化。蛋白质组学研究通过筛选出特定方向的蛋白质表达差异,为进一步研究NP的发病机制、治疗靶点等方面提供了重要参考。Neuropathic pain(NP)is a common pain condition,mainly caused by injury of the nervous system.There are still difficulties in the diagnosis and treatment of NP,and its pathogenesis needs to be further explored.Proteomics is a technology that identifies,analyzes and quantitatively acquires the composition of all proteins in the target tissue,widely used in the research on pathological mechanisms,biomarkers,drug targets,etc.This paper provides a review of the current researches on proteomics in NP.In basic researches,significant changes in protein levels are found in metabolic enzymes,signal transduction,and oxidative stress in animal models of NP.In clinical researches,it was found that diseases,such as postherpetic neuralgia,lead to significant changes in protein levels in oxidative stress and mitogen-activated protein kinase pathways(MAPK pathways),and also in extracellular matrix proteins.Proteomics researches provide important information for further investigation on the pathogenesis and therapeutic targets of NP by screening out the differences in protein expression in specific directions.

关 键 词：神经病理性疼痛 蛋白质组学 差异蛋白质组学 差异表达蛋白 质谱技术 

分 类 号：R741[医药卫生—神经病学与精神病学]