富硒生物活性肽制备技术及其功能研究进展  

Research progress on the preparation technology and function of selenium-enriched bioactive peptide

作　　者：黄继红[1,2,3] 赵朋辉 侯银臣 陈文静 廖爱美 潘龙 李彦瑾 杨盛茹 李琰[4] HUANG Jihong;ZHAO Penghui;HOU Yinchen;CHEN Wenjing;LIAO Aimei;PAN Long;Li Yanjin;YANG Shengru;LI Yan(Henan Key Laboratory of Wheat Bioprocessing and Nutritional Function,College of Biological Engineering,Henan University of Technology,Zhengzhou 450001,China;School of Food and Pharmacy,Xuchang University,Xuchang 461000,China;State Key Laboratory of Crop Stress Adaptation and Improvement,College of Agriculture,Henan University,Kaifeng 475004,China;School of Food and Bioengineering,Henan University of Animal Husbandry and Economy,Zhengzhou 450046,China)

机构地区：[1]河南工业大学生物工程学院,小麦生物加工与营养功能河南省重点实验室,河南郑州450001 [2]许昌学院食品与药学院,河南许昌461000 [3]河南大学农学院,作物逆境适应与改良国家重点实验室,河南开封475004 [4]河南牧业经济学院食品与生物工程学院,河南郑州450046

出　　处：《河南工业大学学报（自然科学版）》2022年第3期125-132,140,共9页Journal of Henan University of Technology：Natural Science Edition

基　　金：河南省科技攻关计划(212102110313);河南省重大公益专项(201300110300);河南省创新示范专项(201111110100)。

摘　　要：硒是人体必不可少的微量元素,具有提高免疫力、抗氧化等重要生物活性,无机硒吸收率低、摄入安全性差,有机硒是目前的研究热点。富硒生物活性肽具有多种功能,以酶解、微生物发酵、金属螯合等方法制备。近年来国内外学者重点关注富硒肽的提取和分离,对其生物活性及生物利用度做了较多的研究。综合国内外相关研究,对富硒生物活性肽的来源及制备方法,抗癌、抗氧化、抗病毒、抗炎等活性和生物利用度等加以讨论,以期为更深入探究其结构及人体吸收、转化机制提供依据。Selenium is an essential trace element in the human body,and has important biological activities such as improving human immunity and anti-oxidation.However,the absorption rate of inorganic selenium is low and the intake safety is poor,hence,organic selenium is the current research focus.Selenium-enriched bioactive peptide is a functional polypeptide,which is mostly prepared by enzymatic hydrolysis,microbial fermentation,metal chelation and other methods.In recent years,scholars at home and abroad have focused on the preparation and separation of selenopeptides,and have also done a lot of research on its biological activity and bioavailability.Based on relevant research at home and abroad,the preparation sources and methods of selenium-enriched bioactive peptides,anticancer,antioxidant,antiviral,anti-inflammatory and other activities,and bioavailability are discussed in order to provide a basis for a more in-depth study of its structure and the mechanism of human absorption and transformation.

关 键 词：富硒生物活性肽 制备 生物活性 生物利用度 

分 类 号：TS201.2[轻工技术与工程—食品科学]