两个CBA亚系流产模型数据比较  

Comparison of abortion model data between two CBA mouse sub-strains

作　　者：王蕾 吴旭颖 高玉龙 张文明 李斌 刘云波 WANG Lei;WU Xuying;GAO Yulong;ZHANG Wenming;LI Bin;LIU Yunbo(Beijing HFK Bioscience CO.,LTD,Beijing 102202,China;Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS),Beijing 100021)

机构地区：[1]北京华阜康生物科技股份有限公司,北京102202 [2]中国医学科学院医学实验动物研究所,北京100021

出　　处：《中国比较医学杂志》2022年第6期76-79,92,共5页Chinese Journal of Comparative Medicine

摘　　要：目的观察了CBA/J和CBA/Ola两个亚系流产模型数据。10~16周龄CBA/J胚胎吸收率为12.8%~22.2%高于10~16周龄CBA/Ola胚胎吸收率的11.4%~13.0%。方法设计CBA/J和CBA/Ola两个亚系的流产模型实验,每个亚系分别6组动物互配并进行观察。六组中三组为10周龄CBA组,另外三组为16周龄CBA组。每个周龄三组包括CBA自交组,BALB/c和CBA互配组和DBA2和CBA互配组。结果CBA/J比CBA/Ola成模率高,且16周雌性CBA/J造模成功率比10周雌性CBA/J高。CBA/J和CBA/Ola亚系本品系互配都存在胚胎吸收问题,原因还有待于进一步研究。结论16周CBA/J雌鼠更适用于流产模型造模。Objective To observe the abortion model data of the CBA/J and CBA/Ola sub-strains of mice.The Embryo resorption rate of 10~16 weeks CBA/J mice was 12.8%~22.2%higher than 11.4%~13.0%of 10~16 weeks CBA/Ola mice.Methods Abortion model experiments on CBA/J and CBA/Ola mice were designed.Each murine subline was matched with six groups of animals and observed.Three of the six groups are 10-week-old female CBA groups and three are 16-week-old female CBA groups.Three groups for each week of age include the mutual mating of CBA,BALB/c and CBA,DBA2 and CBA.Results CBA/J mice have a higher Embryo resorption rate compared with CBA/Ola mice,and the Embryo resorption rate of 16-week-old female CBA/J mice is higher than the rate of 10-week-old female CBA/J.Both the CBA/J and CBA/Ola murine sublines have embryo absorption problems in their mutual mating,the reasons for which need to be further studied.Conclusions 16-week-old CBA/J female mice are more suitable for the establishment of abortion models.

关 键 词：CBA/Ola CBA/J CBA 流产模型 亚系 

分 类 号：R-33[医药卫生]