SARS-CoV-2 奥密克戎变异株的研究进展  

Research progress on the SARS-CoV-2 Omicron mutant

作　　者：刘宏[1] 凌子旭 张净 李思雨 白天科 李剑[3] LIU Hong;LING Zixu;ZHANG Jing;LI Siyu;BAI Tianke;LI Jian(the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Clinical College of Hebei Medical University,Shijiazhuang 050031;Basic Medicine College of Hebei Medical University,Shijiazhuang 050017)

机构地区：[1]河北医科大学第二医院,石家庄050000 [2]河北医科大学临床学院,石家庄050031 [3]河北医科大学基础医学院,石家庄050017

出　　处：《中国比较医学杂志》2022年第6期122-127,共6页Chinese Journal of Comparative Medicine

基　　金：河北省自然科学基金(C2021206004);河北省高等学校科学技术研究项目(QN2021098);河北省中医药管理局科研计划项目(2021118);河北省大学生创新性实验计划项目(CXSY2020002);河北医科大学“春雨计划”项目(CYCZ2021002)。

摘　　要：严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)的新变异株奥密克戎(Omicron,B.1.1.529)因其传染性强和对疫苗的逃逸突变在世界各地引起了广泛关注。SARS-CoV-2变异株的易感染性和抗体抗性主要由病毒刺突(S)蛋白受体结合域(RBD)上的突变决定。然而,对奥密克戎变异株的完整实验评估可能需要数周甚至数月才能完成。在此,研究人员将对奥密克戎株的传染性、疫苗策略以及血清抗体中和活性等方面进行分析,以期为尽快科学了解奥密克戎变异株的关键特性,提早制定长远对策提供思路。The latest severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variant Omicron(B.1.1.529)has incited panic responses around the world owing to its higher level of contagiousness and vaccine-escape mutations.The susceptibility of potential hosts to the SARS-CoV-2 mutant and the antibody resistance of this virus are determined mainly by the mutation in the receptor-binding domain(RBD)of its spike(S)protein.However,a complete experimental evaluation of Omicron may take weeks or even months.Here,we analyze the infectivity,vaccine strategy,and serum antibody neutralization activity of Omicron,the result of which are expected to provide a basis for scientifically understanding the key characteristics of the Omicron mutant as soon as possible and for formulating appropriate long-term countermeasures against SARS-CoV-2.

关 键 词：奥密克戎株 SARS-CoV-2 新型冠状病毒肺炎 变异株 

分 类 号：R-33[医药卫生]