急性期miR-355水平与老年ACI患者日常生活能力康复效果的关系  

Relationship between the level of miRNA-335 in acute stage and the rehabilitation effect of daily living ability in old patients with ACI

作　　者：蒲志强 麦超[1] 曹小平[1] 杨凡慧 PU Zhi-Qiang;MAI Chao;CAO Xiao-Ping(Department of Emergency Medicine,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院急诊内科,四川南充637000 [2]川北医学院附属医院核医学科,四川南充637000

出　　处：《中国老年学杂志》2022年第14期3390-3393,共4页Chinese Journal of Gerontology

基　　金：四川省科技计划项目(No.2021YJ0515)。

摘　　要：目的探讨急性期血清中微小RNA(miR)-355表达与老年急性脑梗死(ACI)患者日常生活能力(ADL)康复效果的关系。方法选取119例ACI患者,采集患者入院72 h内静脉血检测血清miR-355水平,所有患者急性期后在接受康复治疗,根据康复治疗后3个月ADL量表评分将其分为良好组54例、不良组65例;分析两组入院72 h内血清miR-355表达水平、入院时美国国立卫生研究院脑卒中量表(NIHSS)神经功能缺损评分、脑梗死体积、血压、血糖、血脂等基线资料;并采用Logistic回归分析miR-355与患者康复效果的关系。结果良好组血清miR-355相对表达水平高于不良组,差异有统计学意义(P<0.05);两组年龄、性别、体重指数(BMI)、吸烟、饮酒、高脂血症情况差异无统计学意义(P>0.05);两组高血压、糖尿病、NIHSS、脑梗死体积差异有统计学意义(P<0.05);Logistic回归分析显示,伴有糖尿病、入院时NIHSS>15分、大梗死病灶、血清miR-355相对表达降低是ACI患者康复治疗后ADL康复效果不佳的独立危险因素(P<0.05)。结论老年ACI患者康复治疗后ADL康复效果受到多种因素的影响,急性期血清miR-355相对表达降低可能会增大患者康复治疗后ADL恢复不佳的风险。Objective To investigate the relationship between the serum expression of microRNA-355(miR-355)in acute phase and the rehabilitation effect of daily living ability in old patients with acute cerebral infarction(ACI).Methods A total of 119 patients with ACI were selected as the research subjects,and the venous blood of the patients was collected within 72 h of admission to detect the level of serum miR-355.All patients received rehabilitation treatment in the rehabilitation center after the acute phase.54 patients with good recovery(good group)and 65 patients with poor recovery effect(poor group)were divided according to their ADL scores after 3 months of rehabilitation treatment;the serum miR-355 expression level,neurological deficit score of NIHSS on admission,cerebral infarction volume,blood pressure,blood sugar,blood lipids and other baseline data of the two groups of patients within 72 h of admission were statistically analyzed.The relationship between miR-355 expression and patients'rehabilitation effect were analyzed by Logistic regression analysis.Results The relative expression level of serum miR-355 in good group was significantly higher than that in poor group(P<0.05).There were no significant differences in age,gender,BMI,smoking,drinking,and hyperlipidemia between good group and poor group(P>0.05);there were significant differences in hypertension,diabetes,NIHSS score,and cerebral infarction size between good group and poor group(P<0.05);Logistic regression model analysis showed:accompanied by diabetes,NIHSS score>15 points at admission,lesions of major infarction,and the decreased relative expression of serum miR-355 were independent risk factors for poor rehabilitation of daily living ability after rehabilitation treatment in ACI patients(P<0.05).Conclusions The rehabilitation effect of daily living ability in old patients with ACI is affected by many factors.The decrease of the relative expression of miR-355 in the acute phase may increase the risk of poor recovery of daily living ability after reh

关 键 词：急性期 微小RNA-355 急性脑梗死 日常生活能力 康复 

分 类 号：R742[医药卫生—神经病学与精神病学]