双歧杆菌四联活菌片联合四联疗法对HP阳性胃溃疡患者血清TGF-β1、G17、PGI的影响  

Effect of Bifidobacterium tetralogy combined with quadruple therapy on serum TGF-1,G17,and PGI in patients with HP-positive gastric ulcer

作　　者：彭琴 张清[1] PENG Qin;ZHANG Qing(Department of Digestive Endoscopy,the Second People's Hospital of Three Gorges University,Yichang 443000,Hubei,China)

机构地区：[1]三峡大学第二人民医院消化内镜科,湖北省宜昌市443000

出　　处：《中南医学科学杂志》2022年第5期684-686,731,共4页Medical Science Journal of Central South China

基　　金：国家卫生健康委“十三五”规划全国重点课题(YYWS2309)。

摘　　要：目的 探讨双歧杆菌四联活菌片联合四联疗法对幽门螺旋杆菌(HP)阳性胃溃疡患者血清转化生长因子-β1(TGF-β1)、胃泌素17(G17)、胃蛋白酶原I(PGI)的影响。方法 选取HP阳性胃溃疡患者98例,随机均分为对照组和联合组。对照组采用四联疗法,联合组采用双歧杆菌四联活菌片联合四联疗法治疗。比较两组临床疗效、胃黏膜组织学评分、血清TGF-β1、PGI、G17、胃动素(MTL)、不良反应等情况。结果 联合组治疗总有效率高于对照组(P<0.05)。与治疗前比较,治疗后两组胃黏膜组织学各项评分、TGF-β1、G17、PGI均降低,MTL升高,且联合组较对照组更为显著(P<0.05)。联合组不良反应总发生率低于对照组(P<0.05)。结论 双歧杆菌四联活菌片联合四联疗法治疗HP阳性胃溃疡患者疗效满意,可调节胃肠激素水平,安全性良好,具有临床应用价值。Aim To explore the effect of bifidobacterium quadruple viable tablet combined with quadruple therapy on serotransforming growth factor-1(TGF-1),gastrin 17(G17),and pepsinogen I(PGI)in patients with H.py-lori(HP)-positive gastric ulcer.Methods:98 patients with HP positive gastric ulcer were randomly divided into con-trol group and combined group.The control group was treated with tetrad therapy,and the combined group was treated withtetrad therapy combined with bifidobacterium quadruple viable tablet.The clinical efficacy,gastric mucosal histologi-cal score,serum TGF-1,PGI,G17,gastrin(MTL),and adverse effects were compared between the two groups.Re-sults:The total effrctiverate of the combination group was higher than control group(P<0.05).Compared with pre-treatment,the gastric mucosal histology scores,TGF-1,G17,and PGI were decreased,and MTLwasincreased,and the combination group was more significant than control group(P<0.05).The overall incidence of adverse effects in the combination group was lower than that in the control group(P<0.05).Conclusion Bifidobacterium quadruple viable tablet combined with quadruple therapy has a satisfactory curative effect in the treatment of HP-positive gastric ulcer,and can regulate the level of gastrointestinal hormones,with good safety and clinical value.

关 键 词：胃溃疡 幽门螺旋杆菌 四联疗法 双歧杆菌四联活菌片 

分 类 号：R573.1[医药卫生—消化系统]