PTBP1与肿瘤发展和治疗关系的研究进展  

Research Progress on Relation Between BTBP1 and Tumor Progression and Treatment

作　　者：辛彤 孙悦 胡晶[1] XIN Tong;SUN Yue;HU Jing(The Fourth Department of Medical Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院内四科,哈尔滨150081

出　　处：《肿瘤防治研究》2022年第7期715-720,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81972162);黑龙江省自然科学基金优秀青年项目(YQ2019H026);黑龙江省博士后科研启动资助基金(LBH-Q19042);哈尔滨医科大学附属肿瘤医院杰出青年项目(JCQN2020-01)。

摘　　要：多聚嘧啶区结合蛋白1(PTBP1,也被称为hnRNP I)是一种研究广泛的RNA结合蛋白,参与调控mRNA剪接、翻译、稳定性和定位。PTBP1可参与多种非编码RNA的作用过程,影响肿瘤的发生与发展。在肿瘤治疗方面,PTBP1可能作为关键因子影响靶向药物作用靶点以及肿瘤耐药性。本文就PTBP1在肿瘤中的作用及其在肿瘤治疗中的研究进展作一综述。PTBP1,a widely-studied RNA binding protein,regulates mRNA splicing,translation,stability and localization.PTBP1 participates in a variety of ncRNA acting processes,affects tumorigenesis and tumor progression.In terms of tumor therapy,PTBP1 may act as a key factor to affect the target of targeted drugs and influence tumor resistance.This article reviews the role of PTBP1 in tumor and its research progress in tumor treatment.

关 键 词：PTBP1 分子机制 非编码RNA 耐药 

分 类 号：R730.2[医药卫生—肿瘤]