高蛋白、高纤维饮食配合补充支链氨基酸对肝硬化患者营养状况的影响  

Effect of High Protein and High Fiber Diet Combined with Branched Chain Amino Acid Supplementation on Nutritional Status of Patients with Liver Cirrhosis

作　　者：陈翠琳 CHEN Cuilin(Department of Gastroenterology,Huizhou First Hospital,Huizhou,Guangdong,516001)

机构地区：[1]广东省惠州市第一人民医院胃肠-甲状腺外科,广东惠州516001

出　　处：《智慧健康》2022年第14期54-56,59,共4页Smart Healthcare

摘　　要：目的 观察高蛋白和高纤维饮食配合补充支链氨基酸(BCAA)6个月对肝硬化患者营养状况的影响,以及这些患者的安全性和耐受性。方法 本次试验共招募了70名患者,根据电脑随机数表将患者分析对照组和干预组,患者入组后接受2周标准饮食指导。2周后评估对标准饮食的依从性,并在研究开始前剔除依从性差(依从率低于80%)的患者。标准饮食2周后对照组患者的饮食标准为高蛋白、高纤维饮食。干预组在高蛋白、高纤维饮食基础上增加BCAA补充剂。观察患者食疗前后的血氨和血糖水平、上臂中段肌围(MAMC)、三头肌皮皱(TSF)、数字连接测验-A(NCT-A)、数码-符号测验(DST)评分、食疗后生活质量评定问卷(GQOL-74)评分的变化。结果 两组患者食疗前的血氨和血糖水平与食疗结束后比较,差异均无统计学意义(P>0.05);干预组食疗结束后的MAMC较食疗前增大,差异有统计学意义(P<0.05),而食疗结束后干预的TSF则较食疗前减小,差异有统计学意义(P<0.05)。对照组食疗前后的MAMC、TSF差异无统计学意义(P>0.05)。食疗结束后,两组NCT-A和DST评分均无明显变化,差异无统计学意义(P>0.05);两组患者食疗后GQOL-74评分较食疗前,差异无明显统计学意义(P>0.05)。结论 对肝硬化患者来说,补充BCAA加上高蛋白和高纤维饮食是一种安全的干预措施,有助于增加肌肉质量,不会提升血氨和血糖水平,也不会增加肝性脑病的发病率,是临床上值得推荐的一种食疗方法。Objective To observe the effect of high protein and high fiber diet combined with branched chain amino acids (BCAA) supplementation for 6 months on the nutritional status of patients with liver cirrhosis,as well as the safety and tolerance of these patients.Methods A total of 70 patients were recruited in this trial.According to the computer random number table,the patients were analyzed in the control group and the intervention group.The patients were enrolled in the group and received standard dietary guidance for 2 weeks.Compliance with the standard diet was evaluated 2 weeks later,and patients with poor compliance (compliance rate less than 80%) were excluded before the start of the study.After 2 weeks of standard diet,the dietary standard of patients in the control group was high-protein and high-fiber diet.In the intervention group,BCAA supplements were added on the basis of high-protein and high-fiber diet.The levels of blood ammonia and blood glucose,middle upper arm muscle circumference (MAMC),triceps skin wrinkle (TSF),number connection test-A (NCT-A),number-symbol test (DST) and quality of life questionnaire (GQOL-74) were observed before and after dietotherapy.Results There was no significant difference in the levels of blood ammonia and blood glucose between the two groups before and after dietotherapy (P>0.05).In the intervention group,the MAMC after the end of dietotherapy was significantly higher than that before dietotherapy,while the TSF after dietotherapy was lower than that before dietotherapy,and the difference was statistically significant(P<0.05).There was no significant difference in MAMC and TSF in the control group before and after dietotherapy.After dietotherapy,there was no significant difference in NCT-A and DST scores between the two groups (P>0.05).There was no significant difference in GQOL-74 score between the two groups after dietotherapy.Conclusion For patients with liver cirrhosis,supplementation of BCAA plus high-protein and high-fiber diet is a safe intervention,which helps t

关 键 词：支链氨基酸 饮食 肝硬化 营养补充 

分 类 号：R575.2[医药卫生—消化系统]