载脂蛋白E基因多态性与蛛网膜下腔出血相关性的Meta分析  

Correlation between genetic polymorphism of apolipoprotein E and subarachnoid hemorrhage:a Meta-analysis

作　　者：刘军[1] 吴刚[1] 黄玮[2] LIU Jun;WU Gang;HUANG Wei(Department of Neurosurgery,Liuzhou People′s Hospital,Liuzhou 545000,China;Department of Neurosurgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西柳州市人民医院神经外科,柳州市545000 [2]广西医科大学第一附属医院神经外科,南宁市530021

出　　处：《广西医学》2022年第10期1150-1157,共8页Guangxi Medical Journal

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180297)。

摘　　要：目的系统评价载脂蛋白E(ApoE)基因多态性与蛛网膜下腔出血易感性的相关性。方法计算机检索PubMed、Web of Science、Embase、Cochrane Library、中国知网和万方等数据库,纳入ApoE基因多态性与蛛网膜下腔出血的病例对照研究。提取相关数据并评价文献质量后,采用Review Manager 5.3软件进行Meta分析。结果共纳入7篇文献,包括病例组852例、对照组1420例。Meta分析结果显示,ApoE基因的ε2纯合子突变和ε2隐性模型均增加了北高加索人群蛛网膜下腔出血的易感性(均P<0.05),而对亚洲人群均无显著影响(均P>0.05)。其余模型与蛛网膜下腔出血易感性均无相关性(均P>0.05)。结论ApoE基因的ε2纯合子突变和ε2隐性模型与北高加索人群蛛网膜下腔出血的易感性相关,而对亚洲人群蛛网膜下腔出血易感性无明显影响。Objective To systematically evaluate the correlation between gene polymorphism of apolipoprotein E(ApoE)and susceptibility to subarachnoid hemorrhage.Methods Databases such as PubMed,Web of Science,Embase,Cochrane Library,China National Knowledge Infrastructure(CNKI),and Wangfang Data were retrieved by the computer,and the case-control trials on ApoE gene polymorphism and subarachnoid hemorrhage were enrolled.After the extraction of related data and the assessment of quality of literature,Review Manager 5.3 software was employed to conduct Meta-analysis.Results A total of seven literature were enrolled,including the case group with 852 cases and the control group with 1420 cases.The results of Meta-analysis revealed thatε2 homozygote mutation of ApoE gene andε2 recessive model increased susceptibility to subarachnoid hemorrhage in North Caucasians(all P<0.05),whereas there was no significant influence expressed in Asians(all P>0.05).No correlation was found between the remaining models and susceptibility to subarachnoid hemorrhage(all P>0.05).Conclusionε2 homozygote mutation of ApoE gene andε2 recessive model correlate with susceptibility to subarachnoid hemorrhage in North Caucasians;however,there is no significant influence on susceptibility to subarachnoid hemorrhage in Asians.

关 键 词：蛛网膜下腔出血 载脂蛋白E 基因多态性 易感性 北高加索人群 亚洲人群 META分析 

分 类 号：R743.35[医药卫生—神经病学与精神病学]