血清miR-671-3p、miR-135b水平与老年乳腺癌患者化疗耐药性的相关性  

Relationship between serum miR-671-3p,miR-135b levels and drug resistance of chemotherapy in elderly patients with breast cancer

作　　者：余喜梅[1] 张雯捐 龚烨[1] YU Ximei;ZHANG Wenjuan;GONG Ye(Department of Breast and Thyroid Gland,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830001,China;Department of Ophthalmology,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院乳腺甲状腺科,新疆乌鲁木齐830001 [2]新疆维吾尔自治区人民医院眼科,新疆乌鲁木齐830001

出　　处：《国际检验医学杂志》2022年第14期1766-1771,共6页International Journal of Laboratory Medicine

基　　金：新疆维吾尔自治区自然科学基金项目(2018D01C093);国家自然科学基金项目(81560495)。

摘　　要：目的分析血清微小核糖核酸(miR)-671-3p、miR-135b水平与老年乳腺癌患者化疗耐药性的关系。方法回顾性分析2019年1月至2020年2月在该院接受化疗且化疗结束后产生耐药性的52例老年乳腺癌患者作为耐药组,同期选取在该院接受化疗且化疗结束后未产生耐药性的52例老年乳腺癌患者作为敏感组,全部患者均接受6个周期新辅助化疗方案化疗,其患者资料完整,包括一般资料、实验室指标检测结果资料,重点分析化疗前血清miR-671-3p、miR-135b水平与老年乳腺癌患者化疗耐药性的关系。结果耐药组血清miR-671-3p mRNA相对表达量低于敏感组,miR-135b mRNA相对表达量高于敏感组,差异有统计学意义(P<0.05);组间其他实验室指标比较差异无统计学意义(P>0.05);Spearman相关分析结果显示,老年乳腺癌患者血清miR-671-3p mRNA相对表达量与miR-135b mRNA相对表达量呈负相关(r<0,P<0.05);回归分析结果显示,血清miR-671-3p mRNA相对表达量高表达是老年乳腺癌患者化疗耐药性的保护因素(OR<1,P<0.05);miR-135b mRNA相对表达量高表达是老年乳腺癌患者化疗耐药性的危险因素(OR>1,P<0.05);绘制受试者工作特征曲线(ROC曲线),化疗前血清miR-671-3p mRNA相对表达量、miR-135b mRNA相对表达量预测老年乳腺癌患者化疗耐药性风险的曲线下面积均>0.70,预测价值较理想,且联合预测的价值最好。结论血清miR-671-3p mRNA相对表达量、miR-135b mRNA相对表达量与老年乳腺癌患者化疗耐药性有关。Objective To analyze the relationship between serum microRNA(miR)-671-3p and miR-135b levels and drug resistance of chemotherapy in elderly patients with breast cancer.Methods A retrospective analysis was conducted,52 elderly patients with breast cancer who received chemotherapy and had drug resistance after the end of chemotherapy from January 2019 to February 2020 in a hospital were collected,set as the drug-resistant group,52 elderly patients with breast cancer who received chemotherapy and did not have drug resistance after the end of chemotherapy at the same time in a hospital were included,set as sensitive group,all patients received 6 cycles of neoadjuvant chemotherapy regimen for chemotherapy,the patients′data were complete,including general data and data of laboratory index test results,the relationship between serum miR-671-3p and miR-135b levels before chemotherapy and drug resistance of chemotherapy in elderly patients with breast cancer was mainly analyzed.Results The relative expression of miR-671-3p mRNA in drug-resistant group was lower than that in sensitive group,and miR-135b mRNA was higher than that in sensitive group,the differences were statistically significant(P<0.05);There was no statistical significant difference in other laboratory indexes between the groups(P>0.05);The results of Spearman correlation test showed that the relative expression of miR-671-3p mRNA in elderly patients with breast cancer was negatively correlated with the relative expression of miR-135b mRNA(r<0,P<0.05);The results of regression analysis showed that the high expression of miR-671-3p mRNA was the protective factor of drug resistance of chemotherapy in elderly patients with breast cancer(OR<1,P<0.05);The high expression of miR-135b mRNA was a risk factor of drug resistance of chemotherapy in elderly patients with breast cancer(OR>1,P<0.05);The receiver operating curve(ROC)was drawn,the area urder the curve of relative expression of miR-671-3p mRNA and miR-135b mRNA before chemotherapy in predicting the risk o

关 键 词：乳腺癌 化疗 耐药性 miR-671-3p miR-135b 

分 类 号：R737.9[医药卫生—肿瘤]