沉默信息调节蛋白3通过调节线粒体功能保护帕金森模型的研究进展  

Research progress on protective effects of silent information regulator 3 via regulating mitochondrial function in Parkinson’s disease model

作　　者：陈东升 孙支唐[1] 张彩兰 张萌[2] CHEN Dong-Sheng;SUN Zhi-Tang;ZHANG Cai-Lan;ZHANG Meng(Shanxi Medical University,Taiyuan,Shanxi 030001,China;The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,Shaanxi 710061,China)

机构地区：[1]山西医科大学,山西太原030001 [2]西安交通大学第一附属医院神经内科,陕西西安710061

出　　处：《国际神经病学神经外科学杂志》2022年第3期93-96,共4页Journal of International Neurology and Neurosurgery

基　　金：国家自然科学基金青年项目(81801122);陕西省自然科学基础研究青年项目(2020JQ⁃529)。

摘　　要：沉默信息调节蛋白3(SIRT3)是一种NAD+依赖性III型组蛋白去乙酰化酶。SIRT3通过对组蛋白以及多种非组蛋白的去乙酰化,在改善认知、调控衰老、延长寿命等方面起着重要的作用。近期研究发现,在鱼藤酮诱导的帕金森动物模型中,SIRT3过表达可以减轻氧化应激、减少α⁃突触核蛋白(α⁃synuclein)的异常聚集,对帕金森动物模型起到保护作用。该文对SIRT3调节线粒体自噬、氧化应激等研究进行综述,以期为帕金森疾病治疗的基础研究提供参考借鉴。Silent information regulator 3(SIRT3)is a NAD+dependent class III histone deacetylase.SIRT3 plays important roles in improving cognition,regulating aging,and prolonging life by deacetylating histone and nonhistone proteins.Recent studies have demonstrated that over expressed SIRT3 can reduce oxidative stress and the abnormal aggregation ofαsynuclein to exert protective effects in the rotenoneinduced Parkinson’s disease model.In this paper,we review recent research progress on the regulatory role of SIRT3 in mitochondrial autophagy and oxidative stress,and hope to provide a reference for basic research on the treatment of Parkinson’s disease.

关 键 词：帕金森病 沉默信息调节蛋白3 自噬 氧化应激 治疗潜力 

分 类 号：R742.5[医药卫生—神经病学与精神病学]