帕金森-高热综合征研究进展  

Research progress on Parkinsonism-hyperpyrexia Syndrome

作　　者：曾昭豪 汪露 李晓婷 徐叶子 岑燕梅 黄坤玉 毕伟[1] ZENG Zhaohao;WANG Lu;LI Xiaoting;XU Yezi;CEN Yanmei;HUANG Kunyu;BI Wei(Department of Neurology,The First Affiliated Hospital of Jinan University,No.613 Huangpu Road,Tianhe District,Guangzhou 510630,China.)

机构地区：[1]暨南大学附属第一医院神经内科,广州510632 [2]暨南大学药学院

出　　处：《中国神经精神疾病杂志》2022年第4期237-241,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金青年基金(编号:81200930);暨南大学科研培育与创新基金跃升计划项(编号:21617482)。

摘　　要：帕金森-高热综合征(Parkinsonism-hyperpyrexia syndrome,PHS)是帕金森病(Parkinson disease,PD)中罕见且危及生命的神经系统急症,患者表现为恶性高热、肌张力改变,并迅速出现意识障碍。国内缺乏文献对该疾病介绍,医生早期识别困难及治疗延误,影响患者预后。本文对PHS病因诱因、临床表现、发生机制、诊断方法及治疗预防策略进行综述。综述文献发现PHS发生与机体多巴胺能系统的突然减弱有关,早期识别和治疗是改善预后的关键。此外,近几年与脑深部电刺激术装置(deep brain stimulator,DBS)故障相关的PHS也相继报告,提示临床医生应定期检测DBS设备功能及注意多巴胺能药物的合理用药。Parkinsonism-hyperpyrexia syndrome(PHS)is a rare and life-threatening neurological emergency in Parkinson disease that presents with malignant hyperthermia,myodystonia,and rapid deterioration of consciousness.Due to a lack of domestic literature to introduce the disease,it is hard for clinicians to make early recognition and appropriate treatment of PHS,thereby,leading to a poor prognosis.This article reviews the causes,clinical manifestations,pathogenesis,diagnostic methods,and treatment and prevention strategies of PHS.This review found that the occurrence of PHS is related to the sudden weakening of the dopaminergic system,and early identification and treatment are the keys for the improvement in the prognosis.In addition,PHS related to the failure of deep brain stimulator(DBS)devices has also been reported in recent years,suggesting that clinicians should regularly monitor the function of DBS devices and pay attention to the rational use of dopaminergic drugs.

关 键 词：帕金森-高热综合征 帕金森病并发症 神经阻滞恶性综合征 帕金森病撤药恶性综合征 帕金 森病 脑深部电刺激术 多巴胺能药物 

分 类 号：R742.5[医药卫生—神经病学与精神病学]