Sleep deprivation reorganizes the dynamic configurations of default mode network activity during recovery sleep  

作　　者：CUI Yan WU ShengDun ZHAO Shi LONG TianYao JIAN ZhaoXin YU Shuang ZHANG Ge BISWAL Bharat GUO DaQing XIA Yang YAO DeZhong 

机构地区：[1]The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Lab for Neuro Information,Centre for Information in Medicine,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 611731,China [2]Department of Neurosurgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China [3]Chinese Academy of Sciences,Sichuan Translational Medicine Research Hospital,Chengdu 610072,China [4]Research Unit of Neuro Information(2019RU035),Chinese Academy of Medical Sciences,Chengdu 611731,China [5]Department of Biomedical Engineering,New Jersey Institute of Technology,Newark,New Jersey 07102,USA [6]School of Electrical Engineering,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Science China(Technological Sciences)》2022年第7期1456-1469,共14页中国科学（技术科学英文版）

基　　金：supported by the MOST 2030 Brain Project (Grant No.2022ZD0208500);the National Natural Science Foundation of China(Grant Nos. 31771149, 81861128001, and 61933003);partly supported by the CAMS Innovation Fund for Medical Sciences (CIFMS)(Grant No.2019-I2M-5-039)。

摘　　要：Sleep deprivation causes disturbances of the neural activity, leading to the impairment of brain functions. However, the exact mechanism of sleep deprivation and how it affects the dynamics of brain activity during the recovery sleep remains unclear. In the current study, we performed sleep deprivation experiments on ten adult rats, and recorded the local field potentials from default mode network(DMN) regions during sleep before and after sleep deprivation. The DMN dynamics was assessed with the configurations of coactive micropatterns(CAMPs) using our previously proposed CAMP method. Our analysis revealed that the effects of sleep deprivation on DMN dynamics in the slow-wave sleep(SWS) state and the rapid eye-movement sleep(REM)state were disparate. Dynamic configurations of DMN activity in the SWS state were significantly impaired after sleep deprivation, with increased occurrence of low-activity CAMP and reorganized transition structure across three CAMPs. Moreover,enhanced functional connectivity and improved efficiencies in all CAMP networks were observed during the SWS state in the recovery sleep. However, there were no significant alterations in either DMN dynamics or CAMP network structures in the REM sleep state after sleep deprivation. Our results described the alterations of DMN dynamics in different sleep states after sleep deprivation, and illustrated the differential effects of sleep deprivation on two sleep states. These findings demonstrated the underlying neural mechanisms of the effects of sleep deprivation on DMN activity during sleep and increased our understanding of the physiological roles of the DMN in maintain sleep homeostasis after sleep deprivation.

关 键 词：sleep deprivation sleep state default mode network coactive micropattern dynamic configuration EFFICIENCY 

分 类 号：R740[医药卫生—神经病学与精神病学]