mTOR单核苷酸基因多态性与男性酒依赖相关攻击表型的关联性研究  

Association of mTOR single nucleotide polymorphisms with alcohol dependent aggressive phenotypes in males

作　　者：程君[1] 孙广强 倪照军 朱冉 高雪娇[4] 孙洪强[4] CHENG Jun;SUN Guang-qiang;NI Zhao-jun;ZHU Ran;GAO Xue-jiao;SUN Hong-qiang(Affiliated Psychological Hospital of Anhui Medical University,Anhui Mental Health Center,Heifei Fourth People's Hospital,Hefei Medical Research Center on Alcohol Addiction,Hefei 230022,China;The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China;Peking University Sixth Hospital,Peking University Institute of Mental Health,National Health Commission,Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental and Psychological Disorders(The Sixth Hospital of Peking University),Beijing 100191,China)

机构地区：[1]安徽医科大学附属心理医院安徽省精神卫生中心合肥市第四人民医院合肥市酒精成瘾医学研究中心,合肥230022 [2]首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室,北京100088 [3]人脑保护高精尖创新中心首都医科大学,北京100069 [4]北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191

出　　处：《中国药物依赖性杂志》2022年第3期177-182,共6页Chinese Journal of Drug Dependence

基　　金：合肥市第六周期医学重点专科项目。

摘　　要：目的 探讨mTOR单核苷酸基因多态性(rs12137958、rs7525957、rs718206、rs1057079)与酒依赖相关攻击表型的关联。方法 在8家精神专科医院招募291名酒依赖患者,同时期收集212名健康被试,采用Buss-Perry攻击问卷评估攻击行为,采用TaqMan探针和连接酶检测反应进行基因分型。结果 酒依赖组的攻击量表评分显著高于对照组(P<0.001),rs1057079AA基因型个体的攻击量表总分显著高于AG基因型个体(P<0.05/4),且不受酒依赖疾病的影响。结论 男性酒依赖患者的攻击水平升高,且mTOR单核苷酸基因多态性影响男性酒依赖患者的攻击行为。Objective To investigate the association between single nucleotide polymorphisms(rs12137958, rs7525957, rs718206, rs1057079) of mTOR gene and alcohol dependence-related phenotype. Methods The total of 291 alcohol-dependent patients who met the criteria of DSM-Ⅳ were recruited in 8 psychiatric hospitals, and 212 healthy subjects were collected at the same time. Buss-Perry Aggression Questionnaire was used to assess aggression of the participants, and TaqMan probe and ligase detection reaction were used for genotyping. Results The score of aggressive behavior in alcohol dependent patients was significantly higher than that in control group(P<0.001). The aggressive total score of rs1057079 AA genotype individuals were higher than those of AG genotype individuals(P<0.05/4), which was not affected by alcohol dependence disease. Conclusion The level of aggression in male alcohol-dependent patients was higher, and mTOR single nucleotide polymorphisms affected the aggressive behavior in male alcohol-dependent patients.

关 键 词：酒依赖 mTOR基因 单核苷酸基因多态性 攻击行为 

分 类 号：R749[医药卫生—神经病学与精神病学]