雄性激素受体在Ⅰ型和Ⅱ型子宫内膜癌中的差异及其与预后的相关性研究  

Differences of androgen receptor in typeⅠand typeⅡendometrial cancer and its correlation with prognosis

作　　者：黄小杏 刘佳欣 梁秀冰 莫劲思 曾庆苏 HUANG Xiaoxing;LIU Jiaxin;LIANG Xiubing;MO Jinsi;ZENG Qingsu(Department of Pathology,People s Hospital of Yangjiang,Yangjiang 529500,China;Institute of Reproductive Medicine,Guangdong Medical University,Guangzhou 510000,China)

机构地区：[1]广东省阳江市人民医院病理科,广东阳江529500 [2]广东医科大学生殖医学研究所,广东广州510000

出　　处：《空军军医大学学报》2022年第2期198-202,共5页Journal of Air Force Medical University

基　　金：广东省医学科学技术研究基金(A2018059);广东省阳江市医疗卫生科技计划项目(SF2021042)。

摘　　要：目的 研究雄性激素受体(AR)在不同分型的子宫内膜癌(EC)中的表达,以及对患者预后的影响。方法 对2015年1月至2021年5月在广东省阳江市人民医院诊断和治疗的EC病例进行回顾性分析。在入组的156例EC患者中检测了AR的免疫组化表达水平。根据常规诊断标准对EC组织学分型进行了验证(Ⅰ型120例,Ⅱ型36例)。对AR阳性率与不同的临床和组织学参数进行分析,包括年龄、是否绝经、EC类型、肿瘤组织类型、肿瘤分级、雌激素受体表达水平、是否合并非典型复合增生、淋巴结转移情况、复发情况和患者结局。对分类变量采用χ^(2)检验来评估组间的关联。结果 120例患者无病生存,24例带病生存,9例因病死亡,3例因其他原因死亡。33例(21.2%)患者复发。75例(62.5%)EC-Ⅰ和9例(25.0%)EC-Ⅱ为AR阳性。经χ^(2)检验评估,患者肿瘤组织中AR表达阳性率与EC类型、肿瘤分级、肿瘤组织类型、淋巴结转移情况、患者结局存在显著相关性(P<0.05)。结论 AR在EC中普遍表达,其表达水平可能与较低等级、较好分化的EC有关。Objective To investigate the differences in expression of androgen receptors(AR)in different types of endometrial cancer(EC)and their effect on the prognosis of patients.Methods A retrospective analysis of EC cases diagnosed and treated in People s Hospital of Yangjing from January 2015 to May 2021 was performed.Immunohistochemical expression levels of AR were detected in 156 enrolled EC cases.Histological typing was validated according to conventional diagnostic criteria(typeⅠ=120;typeⅡ=36).The rate of positive AR was analyzed in relation to different clinical and histological parameters,including age,whether in menopause,EC type,tumor tissue type,tumor classfication,expression level of estrogen receptor,whether complicated with atypical complex hyperplasia,lymph node metastasis,recurrence,and patient outcome.A chi-square test was applied to categorical variables to assess the association between groups.Results One hundred and twenty patients survived without disease,24 survived with disease,9 died of disease,and 3 died of other causes.Thirty-three(21.2%)patients were found to have a recurrence.Approximately 75 cases(62.5%)of EC-Ⅰand 9 cases(25.0%)of EC-Ⅱwere AR-positive.The rate of positive AR expression in patients tumor tissues was significantly correlated with the following parameters:EC type,trmor classification,tumor tissue type,lymph node metastasis,and patient outcome,as assessed by chi-square test(P<0.05).Conclusion AR is commonly expressed in EC,and its expression level may be related to EC with lower grades and better differentiation.

关 键 词：子宫内膜癌 子宫内膜样腺癌 子宫内膜浆液性癌 子宫内膜透明细胞癌 雄性激素受体 

分 类 号：R737[医药卫生—肿瘤]