中药口服液澄清剂及澄清工艺的研究进展  

Research progress of clarification agent and clarification process of traditional Chinese medicine oral liquid

作　　者：王枫 李柯帆 丁雯 李晓兰 连云岚 裴香萍 WANG Feng;LI Kefan;DING Wen;LI Xiaolan;LIAN Yunlan;PEI Xiangping(Shanxi University of Traditional Chinese Medicine,Jinzhong 030619,China;Institute of Drug Inspection Technology,Shanxi Inspection and Testing Center,Taiyuan 030031,China)

机构地区：[1]山西中医药大学,晋中030619 [2]山西省检验检测中心药品检验技术研究所,太原030031

出　　处：《西北药学杂志》2022年第5期182-185,共4页Northwest Pharmaceutical Journal

基　　金：山西省重点研发计划重点项目(编号:201603D3113021);山西中医药大学科技创新能力培育计划“成果转化引导专项”项目(编号:2020PY-ZH-03)。

摘　　要：目的了解中药口服液中常用的澄清剂及澄清工艺的研究进展。方法通过查阅文献对近年来在中药口服液中常用的澄清剂及澄清工艺进行归纳总结,并从澄清特点、应用和工艺优化等方面进行综述。结果在中药口服液中添加澄清剂,如:ZTC1+1天然澄清剂采用新型“1+1”澄清技术,使澄清效果显著加快;壳聚糖能在去除杂质的同时保留口服液中多糖有效成分;明胶作为水溶性高分子聚合物,具有较好的絮凝性,能有效去除口服液中鞣质等杂质;101果汁澄清剂作为一种食用级吸附澄清剂,应用广泛,主要去除口服液中蛋白质、色素和果胶等大分子物质。以上这几种澄清剂均可有效提高澄清度,减少产品质量安全问题。结论了解中药口服液中常用的澄清剂及澄清工艺的研究进展对提高口服液的质量稳定性具有现实意义,但仍存在一些问题,还需进一步研究。Objective To understand the research progress of the clarification agent and clarification process commonly used in oral solutions of Chinese medicine.Methods The clarification agents and clarification processes commonly used in oral solutions of traditional Chinese medicine were summarized by consulting the literature,and the characteristics,application and process optimization were summarized and studied.Results The addition of clarifying agents such as ZTC1+1 natural clarifier to oral liquid of traditional Chinese medicine adopts the new“1+1”clarification technology,which significantly accelerates the clarification effect.Chitosan can remove impurities while retaining the active ingredients of polysaccharides in the oral solution;As a water-soluble polymer,gelatin has good flocculation and can effectively remove impurities such as tannin in oral liquid;101 Fruit juice clarifier as a kind of edible grade adsorption clarifier,widely used,mainly to remove proteins,pigments and pectin and other macromolecular substances in oral liquid;The above several clarifiers can effectively improve the degree of clarity and reduce product quality and safety problems.Conclusion Understanding the research progress of the clarification agent and clarification process commonly used in oral solutions of Chinese medicine is of practical significance to improve the quality stability of oral fluids,but there are still some problems that need further study.

关 键 词：中药口服液 澄清剂 澄清工艺 

分 类 号：R282[医药卫生—中药学]