HFIP-catalyzed highly diastereoselective formal[4+2]cyclization to synthesize difluorinated multisubstituted chromans using difluoroenoxysilanes as C2 synthons  

作　　者：Jinshan Li Wenxue Xi Saimei Liu Yaqi Yang Jianguo Yang Hanfeng Ding Zhiming Wang 

机构地区：[1]Advanced Research Institute and Department of Chemistry,Taizhou University,Taizhou 318000,China [2]Department of Chemistry,Zhejiang Sci-Tech University,Hangzhou 310018,China [3]Department of Chemistry,Zhejiang University,Hangzhou 310058,China

出　　处：《Chinese Chemical Letters》2022年第6期3007-3011,共5页中国化学快报（英文版）

基　　金：the financial support from the Natural Science Foundation of Zhejiang Province(No.LQ20B020005);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005);Joint Fund of Zhejiang Provincial Natural Science Foundation(No.LTZ21B020001)。

摘　　要：A hexafluoroisopropanol(HFIP)-catalyzed highly diastereoselective formal[4+2]cyclization between ortho-hydroxyphenyl para-quinone methides and difluoroenoxysilanes is developed.This tandem protocol provides a simple and straightforward approach to assemble diverse multiply functionalized difluorinated chromans with high to excellent diastereoselectivity by employing difluoroenoxysilane as a new C2 synthon.

关 键 词：Difluorinated chromans [4+2]Cyclization Difluoroenoxysilanes HFIP catalysis DIASTEREOSELECTIVITY 

分 类 号：O621.251[理学—有机化学]