Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone  

作　　者：Shan Su Duo Hua Jin-Peng Li Xia-Nan Zhang Lei Bai Li-Bo Cao Yi Guo Ming Zhang Jia-Zhen Dong Xiao-Wei Liang Ke Lan Ming-Ming Hu Hong-Bing Shu 

机构地区：[1]Department of Infectious Diseases,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan 430071,China [2]Department of Thyroid and Breast Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [3]State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan 430071,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1783-1796,共14页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the State Key R&D Program of China(2017YFA0505800 and 2021YFA1302400);the National Natural Science Foundation of China(31922021,32170713,31830042,and 31771555);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071).

摘　　要：Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic.We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice.Progesterone induces downstream antiviral genes and promotes innate antiviral response in cells and mice,whereas knockout of the progesterone receptor PGR has opposite effects.Mechanistically,stimulation of PGR by progesterone activates the tyrosine kinase SRC,which phosphorylates the transcriptional factor IRF3 at Y107.

关 键 词：PROGESTERONE METABOLISM STIMULATION 

分 类 号：R373[医药卫生—病原生物学]