Th9细胞的特性、分化调控机制及其与肿瘤免疫  

Characteristics,differentiation regulation mechanism of Th9 cells and their relationship with tumor immunity

作　　者：朱启泰 赵鑫[3] 张积[4] 王雪峰[1] ZHU Qitai;ZHAO Xin;ZHANG Ji;WANG Xuefeng(School of Basic Medicine and Biological Sciences,Suzhou Medical College,Soochow University,Suzhou 215123,China;Department of Central Laboratory,the Affiliated Infectious Diseases Hospital of Soochow University,Suzhou 215007,China;Department of General Surgery,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Ophthalmology,the Second Affiliated Hospital of Suzhou University,Suzhou 215004,China)

机构地区：[1]苏州大学苏州医学院,基础医学与生物科学学院,苏州215123 [2]苏州大学附属传染病医院中心实验室,苏州215007 [3]苏州大学附属第一医院普外科,苏州215006 [4]苏州大学附属第二医院眼科,苏州215004

出　　处：《生命的化学》2022年第5期892-900,共9页Chemistry of Life

基　　金：国家自然科学基金项目(31970833,91642103,31570889,8207112768);江苏省六大人才高峰高层次人才项目(2017-SWYY-065);江苏高校优势学科建设工程资助项目;放射医学与辐射防护国家重点实验室开放课题(GZK1201912);苏州市医学重点学科建设项目(SZFCXK202118)。

摘　　要：Th9细胞是近期发现的新型辅助性CD4^(+)T细胞亚群,以大量分泌白细胞介素-9(interleukin 9,IL-9)等细胞因子为主要特征,可由初始CD4^(+)T细胞经转化生长因子-β(transforming growth factor-β,TGF-β)联合IL-4诱导获得。Th9细胞的分化调控机制较为复杂,目前尚不清楚其关键的特征性转录因子,但已知多种转录因子参与了对Th9细胞分化的调控。在小鼠黑色素瘤过继转移治疗模型中,Th9细胞显示出极显著的抗肿瘤生长作用。本文概述了Th9细胞的生物学特性、分化调控机制、与肿瘤免疫应答的关系及其在肿瘤过继免疫治疗中的作用,试图为探索诱导性能优良的Th9细胞并将之应用于肿瘤过继性免疫治疗,提供有价值的理论基础和研究线索。Th9 is a novel type of helper CD4^(+)T cell subsets explored recently.Th9 subset is mainly characterized by the secretion of interleukin-9(IL-9)and can be differentiated from nave CD4^(+)T cells in the presence of transforming growth factors-β(TGF-β)and IL-4.The regulation of Th9 cell differentiation is complex.At present,its key characteristic transcription factor is not clear,but many transcription factors are known to be involved in the regulation of Th9 cell differentiation.In the adoptive immunotherapy treating mouse melanoma,Th9 cells showed a very significant antitumor effect.This paper aims to summarize the characteristics,differentiation regulation mechanism,relationship with tumor immune response of Th9 subset and its adoptive immunotherapeutic effect on treating tumors,trying to provide valuable theoretical basis and clues for differentiating superior Th9 cells and applying them to tumor adoptive immunotherapy.

关 键 词：TH9细胞 白细胞介素-9 转录因子 肿瘤免疫 肿瘤过继免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]