改良电休克治疗甲基苯丙胺所致精神障碍患者激越症状的对照研究  

A Comparative Study of Modified Electroshock in the Treatment of Agitation in Patients with Methamphetamine-induced Mental Disorders

作　　者：丁毅[1] 王怀坤 段炼[1] 杨欣湖 蓝晓嫦[1] 范妮[1] 黄雄[1] DING Yi;WANG Huaikun;DUAN Lian;YANG Xinhu;LAN Xiaochang;FAN Ni;HUANG Xiong(Guangzhou Brain Hospital,Affiliated Hospital of Guangzhou Medical University,Guangzhou 510370,Guangdong,China)

机构地区：[1]广州医科大学附属脑科医院,广东广州510370

出　　处：《中国药物滥用防治杂志》2022年第6期692-695,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：广州市卫生健康委西医类一般引导项目(编号:20191A010032)。

摘　　要：目的:比较改良电休克治疗(MECT)和氟哌啶醇针剂对甲基苯丙胺所致精神障碍患者的兴奋激越症状的疗效和不良反应。方法:选取2019年5月—2021年1月在广州市某医院收治的伴有激越症状的甲基苯丙胺所致精神障碍患者47例作为研究对象,采用简单随机数字表法分为试验组即MECT组(M组)24例,和对照组即氟哌啶醇组(H组)23例,比较两组临床疗效及不良反应发生情况。结果:治疗后第4天和第8天,两组PANSS激越因子均低于治疗前(P<0.05),但组间比较,差异无统计学意义(P>0.05)。M组TESS总分低于H组,差异有统计学意义(P<0.05);H组肌强直、震颤、静坐不能发生率高于M组,差异有统计学意义(P<0.05)。结论:MECT和氟哌啶醇针剂治疗甲基苯丙胺所致精神障碍患者的激越症状疗效相当,但MECT副作用更少,更有优势。Objective:To compare the efficacy and adverse reactions of modified electroconvulsive therapy(MECT)and haloperidol injection in patients with mental disorders caused by methamphetamine.Methods:A total of 47 patients with mental disorders caused by methamphetamine with agitation symptoms admitted to a hospital in Guangzhou from May 2019to January 2021 were selected as the research objects.They were divided into the experimental group(MECT group)with 24cases and the control group(haloperidol group)with 23 cases by simple random number table method.The clinical efficacy and adverse reactions of the two groups were compared.Results:On the 4 th and 8 th day after treatment,the PANSS agitation factors in the two groups were lower than those before treatment(P<0.05);However,the difference between groups was not statistically significant(P>0.05).The total TESS score in group M was lower than that in group H,and the difference was statistically significant(P<0.05).The incidence of muscle rigidity,tremor and sedentary inability in group H was higher than that in group M,and the difference was statistically significant(P<0.05).Conclusion:MECT and haloperidol injection have similar efficacy in the treatment of agitation symptoms in patients with mental disorders caused by methamphetamine,but MECT has fewer side effects and more advantages.

关 键 词：改良电休克治疗 甲基苯丙胺所致精神障碍 氟哌啶醇 激越症状 

分 类 号：R749[医药卫生—神经病学与精神病学]