银杏酮酯分散片联合替罗非班对脑梗死患者神经营养因子及氧化应激指标的影响  

Effect of Ginkgo Ketone Ester Dispersible Tablets combined with tirofiban on neurotrophic factors and oxidative stress indexes in patients with cerebral infarction

作　　者：张瑜 任晓安 姚莉 程越朋 ZHANG Yu;REN Xiaoan;YAO Li;CHENG Yuepeng(Department of Neurology,Dalian Fifth People’s Hospital,Dalian 116021,Liaoning,China)

机构地区：[1]大连市第五人民医院神经内科,辽宁大连116021

出　　处：《中国药物滥用防治杂志》2022年第6期789-792,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探析银杏酮酯分散片联合替罗非班治疗脑梗死患者的临床疗效。方法:选取本院于2020年2月—2021年5月收治的处于急性期的脑梗死患者80例为研究对象,通过随机数字表法分为对照组、观察组,每组40例。两组均给予常规急性脑梗死对症治疗,在此基础上,对照组给予替罗非班治疗,观察组给予银杏酮酯分散片联合替罗非班治疗,比较两组临床疗效、神经营养因子及氧化应激指标。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)高于对照组,差异有统计学意义(P<0.05);观察组晚期蛋白氧化产物(AOPPs)、丙二醛(MDA)、脂质过氧化氢(LHP)水平低于对照组,差异有统计学意义(P<0.05)。结论:银杏酮酯分散片联合替罗非班治疗脑梗死的效果良好,可有效改善神经营养因子及氧化应激指标,促进疾病恢复。Objective:To explore the clinical efficacy of ginkgo ketoester dispersible tablets combined with tirofiban in the treatment of patients with cerebral infarction.Methods:A total of 80 patients with acute cerebral infarction admitted to our hospital from February 2020 to May 2021 were selected as the research objects,and divided into the control group and the observation group by random number table method,with 40 cases in each group.Both groups were given conventional symptomatic treatment of acute cerebral infarction.On this basis,the control group was given tirofiban,and the observation group was given ginkgol ester dispersible tablets combined with tirofiban.The clinical efficacy,neurotrophic factor and oxidative stress indexes were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Serum brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of advanced protein oxidation products(AOPPs),malondialdehyde(MDA)and lipid hydrogen peroxide(LHP)in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Ginkgo ketoester dispersible tablets combined with tirofiban has a good effect in the treatment of cerebral infarction,which can effectively improve neurotrophic factors and oxidative stress indicators,and promote disease recovery.

关 键 词：银杏酮酯分散片 替罗非班 脑梗死 神经营养因子 氧化应激指标 

分 类 号：R743.33[医药卫生—神经病学与精神病学]