血清循环MYCN基因扩增在神经母细胞瘤预后及复发监测中的应用进展  

Advances of serum circulating MYCN gene amplification in monitoring the prognosis and recurrence of neuroblastoma

作　　者：梁莹[1] 侯广军 张品 王琳琳[1] 于志丹 李利锋 秦红 王焕民 张现伟 张万存 Liang Ying;Hou Guangjun;Zhang Pin;Wang Linlin;Yu Zhidan;Li Lifeng;Qin Hong;Wang Huanmin;Zhang Xianwei;Zhang Wancun(Zhengzhou Municipal Key Laboratory of Precise Diagnosis&Treatment of Pediatric Malignant Tumors,Department of Pediatric Tumour Surgery,Affiliated Children's Hospital,Zhengzhou University,Zhengzhou 450018,China)

机构地区：[1]郑州大学附属儿童医院儿童肿瘤外科,儿童恶性肿瘤精准诊疗重点实验室,郑州450018

出　　处：《中华小儿外科杂志》2022年第6期556-560,共5页Chinese Journal of Pediatric Surgery

基　　金：中国博士后面上项目(2020M672301);河南省科技厅科技攻关项目(202102310068);河南省医学科技攻关项目(LHGJ20190937,LHGJ20190887);河南省儿童遗传代谢性疾病重点实验室开放课题资助项目(SS201902,SS201906);河南省儿童神经发育工程研究中心开放课题资助项目(SG201904,SG201906)。

摘　　要：MYCN基因在神经母细胞瘤(neuroblastoma,NB)细胞生长、凋亡、分化、浸润、转移及血管形成等方面发挥重要作用。临床中,MYCN基因扩增是NB危险度分级的重要指标之一。然而,MYCN基因检测面临检测方法操作复杂、检测成本高及不易获得瘤组织细胞等问题。研究表明,NB患儿血清循环MYCN基因扩增情况与瘤组织中一致,血清循环MYCN基因扩增情况作为NB预后及复发监测指标具有灵敏度高、特异性好、操作简便及无创等优势。因此,血清循环MYCN基因扩增检测有望替代瘤组织中MYCN基因扩增检测,用于NB预后及复发监测。本文通过介绍NB患儿血清循环MYCN基因扩增情况在NB诊断、预后及复发监测中的应用研究进展,并对其未来发展进行展望,以期推进其临床转化应用的速度。MYCN gene plays an important role in proliferation,apoptosis,differentiation,tumor infiltration,metastasis and angiogenesis of neuroblastoma cell.Clinically MYCN gene amplification in cancerous tissue is one important indicator for risk grading of neuroblastoma.However,MYCN detection in cancerous tissues has remained problematic,such as complicated procedures of detection methods,high cost of detection and difficulties of harvesting cancerous tissues.Numerous studies have demonstrated that amplification status of MYCN gene in sera of neuroblastoma is consistent with that in tumor tissue.Seral MYCN gene amplification status offers the advantages of high sensitivity,excellent specificity,simple operation and non-invasiveness as a prognostic and recurrence indicator for neuroblastoma.Therefore seral MYCN gene amplification status is expected to replace MYCN gene amplification status in cancerous tissues and monitor the prognosis and recurrence of neuroblastoma.The applications of MYCN gene amplification status in the diagnosis,prognosis and recurrence monitoring of neuroblastoma were summarized.And future developments of MYCN gene amplification status in neuroblastoma prognostic assessment and recurrence monitoring were discussed for accelerating the pace of clinical transformations.

关 键 词：神经母细胞瘤 血清 MYCN扩增 预后 复发 

分 类 号：R739.4[医药卫生—肿瘤]