Prokaryotic gasdermins:ancestors of eukaryotic counterparts direct the pyroptosis and cell fates  

作　　者：Yingying Liu Chen Zhang Min Wu 

机构地区：[1]Department of Biomedical Sciences,School of Medicine and Health Sciences,University of North Dakota,Grand Forks,ND,USA [2]Laboratory of Microbiology,Wageningen University&Research,Stippeneng 4,6708 WE Wageningen,The Netherlands [3]Biotechnology Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081,People’s Republic of China

出　　处：《Signal Transduction and Targeted Therapy》2022年第6期1868-1869,共2页信号转导与靶向治疗（英文）

基　　金：supported by National Institutes of Health Grants R01 AI109317 and R01 AI138203.

摘　　要：Recently,the role of bacterial gasdermin(bGSDM)has been biochemically characterized and published in Science by Johnson et al.,which bridges the gap in functional understanding of GSDM between prokaryotes and eukaryotes,and also suggests the evolutionary conservation of GSDM-mediated pyroptosis,leading to cell death.1 In addition,the identified bGSDM adds unprecedented insights into understanding of the bacterial immunity.

关 键 词：DEATH bridges 

分 类 号：R36[医药卫生—病理学]