原发性肾上腺淋巴瘤临床特征及预后相关因素分析  

Analysis of clinical features and prognostic factors of primary adrenal lymphoma

作　　者：刘宇[1] 张龙[1] 贾占奎[1] LIU Yu;ZHANG Long;JIA Zhankui(Department of Urology,First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China)

机构地区：[1]郑州大学第一附属医院泌尿外科,郑州450052

出　　处：《临床泌尿外科杂志》2022年第6期452-456,共5页Journal of Clinical Urology

摘　　要：目的:探讨原发性肾上腺淋巴瘤(PAL)临床特征及预后分析。方法:回顾性分析郑州大学第一附属医院2010年5月—2018年9月收治的28例PAL患者的相关资料,采用Kaplan-Meier曲线进行生存分析,并总结影响预后的临床因素。结果:男15例,女13例,男女比例1.15︰1.00;年龄23~77岁,中位年龄60岁;肿瘤最大层面17~175 mm,中位肿瘤最大层面61 mm;出现肾上腺皮质功能减低17例,出现B症状16例。总随访时间2~75个月,中位随访时间33个月;1年总生存率为53.6%,3年总生存率为46.4%;单因素分析治疗方法(P=0.019)、肾上腺皮质功能减低(P=0.018)、疗效是否完全缓解(CR)(P<0.001)、是否进行化疗(P=0.007)、B症状(P=0.031),是影响PAL患者生存时间的因素。结论:PAL是一种非常罕见的实体恶性肿瘤,进展快,Cox多因素分析结果显示化疗(OR=0.101,P=0.008)、疗效CR(OR=0.198,P=0.020)是影响PAL患者生存时间的独立因素。Objective:To investigate the clinical features and prognosis of primary adrenal lymphoma(PAL).Methods:We retrospectively analyzed the relevant data of 28 PAL patients admitted to First Affiliated Hospital of Zhengzhou University from May 2010 to September 2018.The Kaplan-Meier method was used for survival analysis,and the clinical factors affecting the prognosis were analyzed.Results:There were 15 males and 13 females.The male-to-female ratio was 1.15∶1.00,aged 23-77 years old,with a median age of 60 years.The largest tumor size was 17-175 mm,and the median tumor largest size was 61 mm.The adrenal cortex function decreased in some cases.Of 17 cases,16 cases had B symptoms.The total follow-up time was 2-75 months,and the median follow-up time was 33 months.The 1-year overall survival rate was 53.6%,and the 3-year overall survival rate was 46.4%.Univariate analysis showed treatment method(P=0.019),adrenal cortex function reduction(P=0.018),complete response(CR)or not(P<0.001),receiving chemotherapy or not(P=0.007),and B symptoms(P=0.031)were factors that affect the survival time of patients with PAL.Conclusion:PAL is a very rare solid malignant tumor with rapid progress.Cox multivariate analysis showed that chemotherapy(OR=0.101,P=0.008)and therapeutic effect of CR(OR=0.198,P=0.020)are the influence independent factors for survival time of PAL patients.

关 键 词：原发性肾上腺淋巴瘤 临床特征 生存分析 预后 

分 类 号：R736.6[医药卫生—肿瘤]