铁死亡及其在肾癌中的研究进展  

Ferroptosis and its research progress in renal cell carcinoma

作　　者：陈逸凡 吕蔡(审校)[1] CHEN Yifan;LV Cai(Department of Urology,Haikou Hospital Affiliated to Xiangya School of Medicine,Central South University,Haikou,570000,China)

机构地区：[1]中南大学湘雅医学院附属海口医院泌尿外科,海口570000

出　　处：《临床泌尿外科杂志》2022年第6期474-477,482,共5页Journal of Clinical Urology

摘　　要：铁死亡是近年来发现的一种铁依赖的非凋亡程序性细胞死亡,由过度的脂质过氧化引起。作为一种新的细胞死亡方式,铁死亡在癌症治疗方面的应用引起了众多学者的关注,有望成为肿瘤精准治疗的潜在靶点。肾癌是泌尿系统最常见的肿瘤之一,其对于铁死亡有较高的敏感性,目前已有大量研究表明靶向诱导铁死亡可以有效地杀死肾癌细胞并阻止肿瘤的生长,因此,对其进一步研究将有助于我们了解铁死亡与肾癌之间的联系,为肾癌的治疗寻找新的途径。Ferroptosis is an iron dependent non-apoptotic programmed cell death found in recent years,which is caused by excessive lipid peroxidation.As a new way of cell death,the application of ferroptosis in cancer treatment has attracted the attention of many scholars,and is expected to become a potential target for precise tumor treatment.Renal cell carcinoma is one of the most common tumors in the urinary system.It has high sensitivity to ferroptosis.At present,a large number of studies have shown that targeted induction of ferroptosis can effectively kill renal cancer cells and prevent tumor growth.Therefore,further research on renal cell carcinoma will help us understand the relationship between ferroptosis and renal cancer and find a new way for the treatment of renal cancer.

关 键 词：铁死亡 肾癌 肿瘤微环境 

分 类 号：R737.11[医药卫生—肿瘤]