分析化学创新设计性实验——基于响应面法优化中药挥发油提取工艺研究  

Innovative Design Analytical Chemistry Experiment:Optimization in Extraction Process of Volatile Oil from Traditional Chinese Medicine Based on Response Surface Methodology

作　　者：龙旭[1] 唐志书[1] 唐于平 史亚军[1] 孟庆华[1] 靳如意 郭惠[1] LONG Xu;TANG Zhi-Shu;TANG Yu-Ping;SHI Ya-Jun;MENG Qing-Hua;JIN Ru-Yi;GUO Hui(College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046

出　　处：《化学教育（中英文）》2022年第10期112-115,共4页Chinese Journal of Chemical Education

基　　金：陕西高等教育教学改革研究重点攻关项目(21BG041);陕西中医药大学学科创新团队项目(2019-PY02);2021年陕西中医药大学教育教学改革研究项目(21jg10,21jg19,21jg23)。

摘　　要：将响应面法与中草药挥发油提取研究有机融合并考察其抗氧化性能的创新设计性实验面向中药特色专业开设。通过考察料液比、浸泡时间和提取时间等工艺条件,让学生掌握分析化学、无机化学中的提取理论知识。通过对不同工艺条件的响应面分析,让学生掌握响应面优化法的原理及操作步骤。通过对挥发油抗氧化性能的研究,让学生掌握仪器分析中紫外分光光度计的使用。The innovative design experiment was obtained by combining the response surface methodology with the research on the extraction of Chinese herbal volatile oil and after investigating its antioxidant activity.Then,this innovative design experiment is set up for the specialty of traditional Chinese medicine.By discussing the process conditions such as the solid-liquid ratio,soaking time,and extraction time,the students can master the theoretical knowledge of extraction in analytical chemistry and inorganic chemistry.Through response surface analysis of different process conditions,the students can master the principle and operation steps of the response surface optimization method.Through the study of the antioxidant properties of volatile oil,the students can make clear the use of ultraviolet spectrophotometer in instrumental analysis.To sum up,the implementation of this innovative design experiment not only improves students’mastery of basic experimental skills but also improves students’innovative ability and comprehensive scientific research ability.

关 键 词：分析化学 综合实验 挥发油 响应面法 

分 类 号：R284.2[医药卫生—中药学]