A targeted nanoplatform co-delivery of pooled siRNA and doxorubicin for reversing of multidrug resistance in breast cancer  

作　　者：Hongmei Liu Ding Ma Jinpeng Chen Li Ye Yiping Li Yuexia Xie Xue Zhao Hanbing Zou Xiaojing Chen Jun Pu Peifeng Liu 

机构地区：[1]State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China [2]Central Laboratory,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [3]Department of Biliary-Pancreatic Surgery,Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital,Shanghai 200127,China [4]Thyroid Breast Surgery,Nantong First People’s Hospital,Nantong 226001,China [5]Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

出　　处：《Nano Research》2022年第7期6306-6314,共9页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.81771968,82003166,and 21704061);the Natural Science Foundation of Shanghai(No.21ZR1439200);Shanghai Sailing Program(No.17YF1411000);Shanghai Municipal Education Commission-Gaofeng Clinical Grant Support(No.20181705);Shanghai Municipal Commission of Health and Family Planning(No.201840020);the Medical-Engineering Joint Funds from the Shanghai Jiao Tong University(Nos.ZH2018ZDA05 and YG2016QN54)on this work.

摘　　要：Multi-drug resistance(MDR)has become the largest obstacle to the success of cancer patients receiving traditional chemotherapeutics or novel targeted drugs.Here,we developed a targeted nanoplatform based on biodegradable boronic acid modifiedε-polylysine to co-deliver P-gp siRNA,Bcl-2 siRNA,and doxorubicin for overcoming the challenge.The targeted nanoplatform showed a robust suppressing efficiency for the invasion,proliferation,and colony formation of adriamycin(ADR)resistant breast cancer cell line(MCF-7/ADR)cells in vitro.The ATP responsiveness of the nanoplatform was also proved in the research.In the in vivo antitumor experiment,the targeted nanoplatform showed a significant inhibition of tumor growth with good biocompatibility.The goal of this study is to develop a novel and facile strategy to prepare a highly efficient and safe gene and drug delivery system for MDR breast cancer based on biocompatibleε-polylysine polymers.

关 键 词：multi-drug resistance(MDR) breast cancer adenosine triphosphate(ATP)responsiveness Ε-POLYLYSINE 

分 类 号：R73[医药卫生—肿瘤]