Dual-modality magnetic resonance/optical imaging-guided sonodynamic therapy of pancreatic cancer with metal-organic nanosonosensitizer  

作　　者：Yingli Chen Bo Yin Zhuang Liu Han Wang Zi Fu Xiuru Ji Wei Tang Dalong Ni Weijun Peng 

机构地区：[1]Shanghai Institution of Medical Imaging,Fudan University,Shanghai 200032,China [2]Department of Radiology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China [3]Department of Radiology,Huashan Hospital,Fudan University,Shanghai 200040,China [4]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Nano Research》2022年第7期6340-6347,共8页纳米研究（英文版）

基　　金：We greatly acknowledge the financial support from the National Natural Science Foundation of China(No.82102190);Shanghai Municipal Education Commission--Gaofeng Clinical Medicine Grant Support(No.20191805);the Foundation of National Facility for Translational Medicine(Shanghai)(No.TMSK-2021-122);this work was also supported,in part,by China Postdoctoral Science Foundation(No.2020M681326);Shanghai Sailing Program(No.19YF1410100);Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01);ZJ Lab,Shanghai Center for Brain-Inspired Technology.

摘　　要：Sonodynamic therapy(SDT)has been more attractive to carry out oncology treatments in recent years.However,imagingguided sonodynamic therapeutic nanomedicine is still a shortage in SDT development.In this work,we designed and fabricated an organic SDT system based on combination of 1,2,4,5-tetrakis(4-carboxyphenyl)-porphyrin(TCPP)and gadolinium(III)(Gd^(3+))creatively(Gd-PPNs).Gd^(3+)was traditionally used to be T_(1)-weighted magnetic resonance imaging(MRI)contrast agent and TCPP was initiatively a fluorescence imaging organic media.Therefore,these new designed nanoparticles have immense potential to integrate MRI and FLI to visualize the Gd-PPNs accumulating and keeping in tumor for a long time,which could be applied for guidance of SDT on tumors in clinical practice.Importantly,excellent SDT efficiency under imaging guidance was verified both in vitro and in vivo in this work.Our findings suggested that Gd-PPNs,as innovative imaging and therapy combinational nanomedicines,were successfully synthesized and were proved to possess excellent imaging-guided sonodynamic therapeutic efficacy.Moreover,this new designed sonosensitizer had great biocompatibility to avoid unnecessary biotoxicity.Overall,this strategy shed light on the MRI/FLI-guidance and successfully induced pancreatic tumor growth inhibition by sonodynamic therapy.

关 键 词：pancreatic tumor sonodynamic therapy THERANOSTICS magnetic resonance imaging 

分 类 号：R735.9[医药卫生—肿瘤]