许旺细胞源性外泌体促进损伤周围神经的修复与再生  

Schwann cell-derived exosomes promote the repair and regeneration of injured peripheral nerves

作　　者：袁博 谢利德[1] 付秀美[1,3] Yuan Bo;Xie Lide;Fu Xiumei(Chengde Medical University,Chengde 067000,Hebei Province,China;Chengde Nursing Vocational College,Chengde 067000,Hebei Province,China;Hebei Key Laboratory of Nerve Injury and Repair,Chengde 067000,Hebei Province,China)

机构地区：[1]承德医学院,河北省承德市067000 [2]承德护理职业学院,河北省承德市067000 [3]河北省神经损伤与修复重点实验室,河北省承德市067000

出　　处：《中国组织工程研究》2023年第6期935-940,共6页Chinese Journal of Tissue Engineering Research

基　　金：河北省科技厅自然科学基金项目(H20214066056),项目负责人:付秀美;河北省教育厅重点项目(ZD2020178),项目负责人:付秀美;河北省科技厅“技术创新引导专项-科技工作会商”项目。

摘　　要：背景:周围神经损伤是临床上的常见创伤。目前短距离神经损伤可以进行端-端吻合,长距离神经损伤常需要移植物桥接。许旺细胞源性外泌体可以提高神经元存活率、改善再生微环境、促进轴突再生,在周围神经损伤与修复领域具有很好的应用前景。目的:综述许旺细胞源性外泌体在周围神经损伤后再生修复中的研究进展。方法:检索PubMed数据库、万方数据库和中国知网(CNKI)2000-2022年的相关文章。中文检索词:“许旺细胞,雪旺细胞,施万细胞,外泌体,细胞外囊泡,周围神经,外周神经,坐骨神经”;英文检索词:“Schwann cell,exosomes,vesicles,peripheral nerve,sciatic nerve”,对初步检索的文献根据纳入、排除标准进行筛选,共纳入52篇文献进行深度分析。结果与结论:①许旺细胞的增殖和迁移对周围神经损伤后的再生修复发挥重要作用,有多种信号通路介入受损周围神经的再生修复;②外泌体可以通过转移生物活性物质介导细胞间通讯以维持正常的生理过程,在周围神经损伤的修复治疗方面具有很大的潜力;③许旺细胞源性外泌体可以通过参与轴突再生和生长调节,发挥促进损伤神经再生修复的作用,为周围神经损伤的临床治疗提供理论依据。BACKGROUND:Peripheral nerve injury is a common clinical trauma.At present,the end-to-end anastomosis was commonly used in the treatment of short-distance nerve injury,whereas graft bridging was required in the long-distance nerve injury.Schwann cell-derived exosomes could elevate neuronal survival,improve the regeneration microenvironment,promote axonal regeneration,and have a good application prospect in the field of peripheral nerve injury and repair.OBJECTIVE:To review the research progress of Schwann cell-derived exosomes in repair and regeneration after peripheral nerve injury.METHODS:The relevant articles published from 2000 to 2022 were searched from PubMed,Wanfang,and CNKI databases by computer.The Chinese and English search terms were“Schwann cell,exosomes,vesicles,peripheral nerve,sciatic nerve”.The preliminary searched articles were screened according to the inclusion and exclusion criteria,and a total of 52 articles were included for in-depth analysis.RESULTS AND CONCLUSION:(1)The proliferation and migration of Schwann cells play an important role in the repair and regeneration after peripheral nerve injury.Schwann cells could promote the regeneration and repair of injured peripheral nerves through a variety of signal transduction pathways.(2)Exosomes could mediate intercellular communication by transferring bioactive substances to maintain normal physiological processes,which had a great potential in the treatment of peripheral nervous system damage.(3)Schwann cell-derived exosomes played a role in promoting regeneration and repair of peripheral nerve injury by participating in axon regeneration and growth regulation so as to provide a new therapeutic strategy for peripheral nerve injury.

关 键 词：外泌体 许旺细胞 周围神经 轴突再生 损伤与修复 基因工程 组织工程 信号通路 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R722.144