Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy  

作　　者：Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan 

机构地区：[1]Henan Key Laboratory of Diamond Optoelectronic Materials and Devices,Key Laboratory of Material Physics,Ministry of Education,and School of Physics and Microelectronics,Zhengzhou University,Zhengzhou,China [2]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,China [3]Henan Key Laboratory for Pharmacology of Liver Diseases,Institute of Medical and Pharmaceutical Sciences,Zhengzhou University,Zhengzhou,China [4]Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,China [5]Joint Key Laboratory of the Ministry of Education,Institute of Applied Physics and Materials Engineering,University of Macao,Macao,China

出　　处：《SmartMat》2022年第2期269-285,共17页智能材料（英文）

基　　金：the National Natural Science Foundation of China(Nos.12074348,U2004168,U1904142,and U21A2070);the China Postdoctoral Science Foundation(No.2020M682310);the Natural Science Foundation of Henan Province(No.212300410078);Science and Technology Department of Henan Province(No.182102410010).

摘　　要：Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.

关 键 词：cancer therapy carbon nanogels CHEMILUMINESCENCE inflammation imaging 

分 类 号：R73[医药卫生—肿瘤]