酒精性肝硬化与非酒精性脂肪性肝硬化的临床特征比较  

Retrospective analysis of the clinical characteristics in patients of alcoholic cirrhosis and non-alcoholic fatty cirrhosis

作　　者：王天懿[1] 李鑫[1] 徐有青[1] Wang Tianyi;Li Xin;Xu Youqing(Department of Gastroenterology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院消化内科,北京100070

出　　处：《中国医刊》2022年第8期848-850,共3页Chinese Journal of Medicine

基　　金：首都卫生发展科研专项课题(首发2020-1-2171)。

摘　　要：目的分析酒精性肝硬化与非酒精性脂肪性肝硬化患者的临床特征。方法回顾性分析2010年1月至2020年1月首都医科大学附属北京天坛医院消化内科收治的125例肝硬化患者的临床资料,根据初诊诊断是否为酒精性肝硬化分为酒精性肝硬化组(93例)和非酒精性脂肪性肝硬化组(32例)。比较两组患者的临床特征。结果酒精性肝硬化组男性显著较多,发病年龄(47.81±15.44)岁,体重指数(20.81±6.24)kg/cm^(2),空腹血糖(5.63±1.81)mmol/L,均显著低于非酒精性脂肪性肝硬化组,差异有显著性(P<0.05)。与非酒精性脂肪性肝硬化组比较,酒精性肝硬化组蜘蛛痣和肝病面容患者比例较高,代谢综合征史比例较低,平均红细胞体积、天冬氨酸氨基转移酶水平、血清总胆红素水平、凝血酶原时间、Child-Pugh C级患者比例较高,差异均有显著性(P<0.05)。结论酒精性肝硬化患者男性较多,发生肝硬化的年龄较轻,易发生营养不良,且病情进展较快。Objective To analyze the clinical characteristics in patients of alcoholic cirrhosis and non-alcoholic fatty cirrhosis.Method Patients newly diagnosed with alcoholic cirrhosis and non-alcoholic fatty cirrhosis in Beijing Tiantan Hospital from January 2010 to January 2020 were included and analyzed.There were 93 cases of alcoholic cirrhosis and 32 cases of non-alcoholic fatty cirrhosis.Result Alcoholic cirrhosis were more common in men with an average age of(47.81±15.44)years.Its characteristics were that body mass index was(20.81±6.24)kg/cm^(2)and fasting blood glucose was(5.63±1.81)mmol/L,which were significantly lower than those of non-alcoholic fatty cirrhosis(P<0.05).Moreover,compared with the non-alcoholic fatty cirrhosis group,the alcoholic cirrhosis group had a higher proportion of patients with spider nevus and hepatic facies,a lower proportion of patients with metabolic syndrome history,and a higher proportion of patients with average erythrocyte volume,aspartate aminotransferase,serum total bilirubin,prothrombin time and Child-Gugh grade C(P<0.05).Conclusion Alcoholic cirrhosis often occurs in young patients,mostly in male patients.Patients with alcoholic cirrhosis often suffer from malnutrition,and the disease progresses rapidly.

关 键 词：酒精性肝硬化 非酒精性脂肪性肝硬化 临床特征 

分 类 号：R575.2[医药卫生—消化系统]