血浆输注治疗一氧化碳中毒迟发性脑病的临床效果  

Clinical effect of plasma infusion in the treatment of delayed encephalopathy after carbon monoxide poisoning

作　　者：姬晓昙 卢启秀[1] 颜丙旺 王理祥 刘厚林[1] JI Xiaotan;LU Qixiu;YAN Bingwang;WANG Lixiang;LIU Houlin(Department of Neurology,Jining NO.1 People′s Hospital,Shandong Province,Jining272000,China)

机构地区：[1]山东省济宁市第一人民医院神经内科,山东济宁272000

出　　处：《中国当代医药》2022年第19期94-97,共4页China Modern Medicine

摘　　要：目的观察血浆输注治疗一氧化碳中毒迟发性脑病(DEACMP)患者的临床效果。方法选取2017年7月至2021年5月济宁市第一人民医院收治的70例DEACMP患者作为研究对象,采用随机数字表法将其分为对照组与试验组,每组各35例。对照组患者采用常规内科治疗,试验组患者在对照组基础上采用血浆输注治疗。比较两组患者的蒙特利尔认知评估量表(MoCA)评分、临床疗效及日常生活能力评分。结果治疗前,两组患者的MoCA、日常生活能力评分比较,差异无统计学意义(P>0.05)。治疗后14 d,两组患者的MoCA评分比较,差异无统计学意义(P>0.05);治疗后14 d,两组患者的MoCA评分高于治疗前,差异有统计学意义(P<0.05)。治疗后3个月,试验组患者的日常生活能力评分高于对照组和治疗前,差异有统计学意义(P<0.05)。试验组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论在常规内科治疗的基础上联合采用血浆输注治疗DEACMP患者可以有效改善其认知功能,提高其日常生活能力。Objective To observe the clinical effect of plasma infusion in the treatment of delayed encephalopathy after carbon monoxide poisoning(DEACMP).Methods A total of 70 patients with DEACMP admitted to Jining NO.1 People′s Hospital from July 2017 to May 2021 were selected as the research objects,and they were divided into the control group and the experimental group according to random number table method,with 35 cases in each group.The control group was treated with routine medical treatment,while the experimental group received plasma infusion therapy on the basis of the control group.The Montreal cognitive assessment(MoCA)score,clinical effect,daily living ability score were compared between the two groups.Results Before treatment,there were no significant differences in the scores of MoCA and daily living ability between the two groups(P>0.05).After treatment of 14 days,there was no significant difference in MoCA scores between the two groups(P>0.05).After treatment of 14 days,the MoCA scores of the two groups were higher than those before treatment(P<0.05).After treatment of three months,daily living ability score in the experimental group was higher than that in the control group and before treatment,the difference was statistically significant(P<0.05).The treatment total effective rate of in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combined use of plasma infusion therapy on the basis of routine medical treatment can effectively improve the cognitive function and daily living ability in DEACMP patients.

关 键 词：血浆输注 一氧化碳中毒 迟发性脑病 认知功能 日常生活能力 

分 类 号：R749.6[医药卫生—神经病学与精神病学]