H2A.Z contributes to trithorax activity at the AGAMOUS locus  

作　　者：Un-Sa Lee Tomasz Bieluszewski Jun Xiao Ayako Yamaguchi Doris Wagner 

机构地区：[1]University of Pennsylvania,Department of Biology,19108 Philadelphia,PA,USAUniversity of Pennsylvania,Department of Biology,19108 Philadelphia,PA,USA [2]Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing,100190,China [3]Centre of Excellence for Plant and Microbial Science(CEPAMS),The John Innes Centre,Norwich Research Park,Norwich,NR47UH,UK

出　　处：《Molecular Plant》2022年第2期207-210,共4页分子植物（英文版）

基　　金：funded by National Science Foundation grant MCB1916431 to D.W.

摘　　要：Dear Editor,In multicellular eukaryotes,Polycomb repression heritably si-lences gene expression programs not needed or detrimental for a given developmental stage or tissue(Schuettengruber et al.,2017).During cell fate reprogramming,Polycomb silencing can be overcome by the combined activity of multiple Trithorax group(TrxG)proteins(Wu et al.,2012;Liang et al.,2015;Schuettengruber et al.,2017).TrxG proteins are genetically defined as suppressors of homeotic defects caused by loss of Polycomb function and have diverse enzymatic activities(Schuettengruber et al.,2017).We used a genetic enhancer screen to identify candidate TrxG proteins and uncovered TrxG activity for components of the SWR1 chromatin remodeling complex,which deposits the histone variant H2A.Z(Deal et al.,2007;March-Diaz et al.,2008).

关 键 词：H2A.Z SUPPRESSOR 

分 类 号：Q943[生物学—植物学]