融入有机电化学合成发展前沿的《药物合成反应》教学改革探索  

Exploration on Integration of Development Frontier of Electrochemical Synthesis into Organic Reactions for Drug Synthesis Teaching Reform

作　　者：牟学清 崔宝东 Mou Xueqing;Cui Baodong(School of Pharmacy,Zunyi Medical University,Zunyi 563006,China)

机构地区：[1]遵义医科大学药学院,贵州遵义563006

出　　处：《广东化工》2022年第14期187-189,共3页Guangdong Chemical Industry

基　　金：教育部第二批新工科研究与实践项目(基金编号:E-HGZY20202027);遵义医科大学2021年校级课程思政改革试点建设项目(基金编号:XJKCSZ-2021-3)。

摘　　要：有机电化学合成反应是一种温和、高效、可控的药物绿色合成技术。本文简要介绍有机电化学合成的前沿科技结果,包括最新的电化学反应类型、光电协同催化、电酶协同催化、不对称有机电化学合成及其相关的工业化运用。结合课程特点和授课团队在有机电合成方面的研究成果,我们探索在氧化反应、还原反应、立体选择性控制等章节的教学活动中分别融入有机电化学阳极氧化反应、阴极还原反应及其电参与的协同催化反应的前沿科技成果。同时,通过指导学生开展有机电合成相关的课程设计、大创项目和竞赛等活动进一步提升学生对有机电化学合成反应的理解与运用能力。该项教学改革初步取得了良好的教学效果,期望为绿色有机电化学理念的推广和绿色制药人才的培养提供一定的借鉴和参考。Synthetic organic electrochemical method under catalyst-and chemical oxidant-free conditions is a mild,efficient,controllable and green drug synthesis strategy.In this paper,the advances in electro-organic synthesis are briefly introduced,including the latest electrochemical synthesis,electrophotocatalytic reaction,electro-enzymatic reaction,asymmetric electrochemical transformation and their industrial applications.Based on the characteristics of the course and our latest research results in electrosynthesis,we integrated electrochemical anodic oxidation reaction,cathodic reduction and the co-catalytic strategy of electricity into the teaching contents of oxidation reaction,reduction reaction and stereoselectivity respectively.At the same time,students’ understanding and application ability of organic electrochemical synthesis reaction was strengthened through organic electrochemical synthesis design projects,creative projects and competitions.The project has achieved certain teaching objective,and it is expected to provide some reference for the promotion of electrochemical synthesis and the cultivation of pharmaceutical talents.

关 键 词：药物合成反应 有机电合成 光电协同催化 电酶协同催化 课程教学改革 

分 类 号：TQ[化学工程]