NSE、CA15-3联合CA125检测在肺癌诊断中的临床意义  

Clinical Significance of NSE, CA15-3 Combined with CA125 Detection in the Diagnosis of Lung Cancer

作　　者：周再稳 肖华 江婷 谢琦 ZHOU Zai-wen;XIAO Hua;JIANG Ting;XIE Qi(Department of Laboratory Tuanfeng County People's Hospital,Tuanfeng 438800,Hubei Province,China)

机构地区：[1]团风县人民医院检验科,湖北团风438800

出　　处：《罕少疾病杂志》2022年第8期39-41,68,共4页Journal of Rare and Uncommon Diseases

摘　　要：目的探究神经元特异性烯醇化酶意义。方法选取2019年5月至2021年5月本院收治的肺癌患者100例纳入肺癌组,选取同期在本院诊治的肺部良性病变患者30例为良性病变组,另选同期健康体检者35例为对照组。对3组受试者的NSE、CA15-3以及CA125水平进行检测,并分析上述指标水平与肺癌临床特征、分期的关系以及各指标表达水平的相关性,并对上述指标及其联合在肺癌诊断中的价值进行探析。结果在NSE、CA15-3以及CA125水平比较上,肺癌组>良性病变组>对照组(P<0.05)。NSE在SCLC中的水平高于其他类型肺癌(P<0.05);CA15-3在鳞癌中的水平高于其他类型肺癌(P<0.05);CA125在腺癌中的水平其他类型肺癌(P<0.05)。NSE、CA15-3、CA125在各型肺癌Ⅳ期的表达水平均高于Ⅰ~Ⅲb期(P<0.05);有胸水肺癌患者NSE、CA15-3、CA125水平均高于无胸水肺癌患者(P<0.05)。NSE、CA15-3、CA125各指标间均存在正相关关系(P<0.05)。NSE、CA15-3、CA125及其联合诊断肺癌的AUC分别为0.702、0.650、0.596和0.853,联合诊断的效能明显优于NSE、CA15-3、CA125单一指标检测(P<0.05)。结论NSE、CA15-3、CA125在肺癌患者中表达异常,且在肺癌诊断、病理类型以及临床分期中均有一定的价值,上述指标联合检测有助于提高肺癌的诊断以及肺癌高危人群的筛查。Objective To explore the significance of neuron-specific enolase(NSE),peripheral blood carcinoembryonic antigen 15-3(CA15-3)combined with carbohydrate antigen 125(CA125)detection in the diagnosis of lung cancer.Methods From May 2019 to May 2021,100 patients with lung cancer who were treated in our hospital were selected and included in the lung cancer group,30 patients with benign lung lesions who were diagnosed and treated in our hospital during the same period were selected as the benign lesion group,and 35 healthy subjects during the same period were selected.Example is the control group.The NSE,CA15-3 and CA125 levels of the subjects in the three groups were detected,and the relationship between the above index levels and the clinical characteristics and stages of lung cancer and the correlation of the expression levels of each index were analyzed,and the above indexes and their combinations were used in the diagnosis of lung cancer.value in the analysis.Results In terms of NSE,CA15-3 and CA125 levels,lung cancer group>benign lesion group>control group(P<0.05).The level of NSE in SCLC was higher than that in other types of lung cancer(P<0.05);the level of CA15-3 in squamous cell carcinoma was higher than that in other types of lung cancer(P<0.05);the level of CA125 in adenocarcinoma was higher in other types of lung cancer(P<0.05).The expression levels of NSE,CA15-3 and CA125 in various types of lung cancer in stage IV were higher than those in stage I-IIIb(P<0.05);the levels of NSE,CA15-3 and CA125 in lung cancer patients with pleural effusion were higher than those in patients without pleural effusion(P<0.05).There were positive correlations among NSE,CA15-3 and CA125 indexes(P<0.05).The AUCs of NSE,CA15-3,CA125 and their combination in diagnosing lung cancer were 0.702,0.650,0.596 and 0.853,respectively,and the combined diagnosis efficiency was significantly better than that of NSE,CA15-3 and CA125 single index detection(P<0.05).Conclusion NSE,CA15-3 and CA125 are abnormally expressed in lung cancer patien

关 键 词：肺癌 神经元特异性烯醇化酶 外周血癌胚抗原15-3 糖类抗原125 病理特征 临床分期 

分 类 号：R734.2[医药卫生—肿瘤]