新生儿感染肝炎相关病毒后对其肝脏损伤的影响  

Effect of Hepatitis Associated Virus Infection on Liver Injury in Neonates

作　　者：卢山 闫风林 LU Shan;YAN Feng-Lin(Department of Pediatric,Pingqiao District Traditional Chinese Medicine Hospital,Xinyang 464194,Henan Province,China;Department of Neonatology,Xinyang Central Hospital,Xinyang 464000,Henan Province,China)

机构地区：[1]信阳市中医院儿科,河南信阳464194 [2]信阳市中心医院新生儿科,河南信阳464000

出　　处：《罕少疾病杂志》2022年第8期57-59,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的研究新生儿感染肝炎相关病毒后对其肝脏损伤的影响。方法选取信阳市平桥区中医院儿科2017年6月至2020年6月期间收治的100例新生儿肝炎患儿,根据有无肝炎相关病毒感染分为感染组(n=64)和无感染组(n=36),并选取同期100例新生儿为健康对照组;检测肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、直接胆红素(DBIL)、总胆红素(TBIL)、总胆汁酸(TBA)、碱性磷酸酶(ALP)],并采用ROC曲线评估其对病毒感染的预测价值。结果感染组ALT、AST、DBIL、TBIL、TBA、ALP高于无感染组与健康对照组(t_(感染组vs无感染组)=13.347、11.705、12.054、11.467、10.695、10.374,P_(感染组vs无感染组)均为0.000;t_(感染组vs健康对照组)=43.244、43.285、50.261、51.120、52.086、45.734,P_(感染组vs健康对照组)均为0.000)。无感染组ALT、AST、DBIL、TBIL、TBA、ALP高于健康对照组(t_(无感染组vs健康对照组)=36.319、37.451、47.961、49.212、50.637、41.664,P_(无感染组vs健康对照组)均为0.000)。单一病毒感染患儿ALT、AST、DBIL、TBIL、TBA、ALP低于复合病毒感染(t_(单一病毒感染vs复合病毒感染)=3.977、2.885、2.713、2.979、2.911、3.002,P_(单一病毒感染vs复合病毒感染)=0.000、0.005、0.008、0.004、0.004、0.003)。ROC显示,ALT、AST、DBIL、TBIL、TBA、ALP对病毒感染具有预测价值(P<0.05)。结论肝炎相关病毒感染可加重新生儿肝炎患儿肝损伤,临床诊治中应重视复合病毒感染,避免肝功能损害加剧。Objective To study the effect of hepatitis associated virus infection on liver injury in neonates.Methods A total of 100 neonates with hepatitis were selected,and divided into infection group(n=64)and non-infection group(n=36)according to the presence or absence of hepatitis-related virus infection.100 healthy neonates were selected as the healthy control group at the same time.The liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),direct bilirubin(DBIL),total bilirubin(TBIL),total bile acid(TBA),alkaline phosphatase((ALP)]were detected,and their predictive value for viral infection was analyzed using the receiver operating characteristic(ROC)curve.Results The levels of ALT,AST,DBIL,TBIL,TBA and ALP in the infection group were significantly higher than those in the non-infection group and the healthy control group(tinfection group vs non-infection group=13.347,11.705,12.054,11.467,10.695,10.374,P infection group vs non-infection group=0.000,t infection group vs healthy control group=43.244,43.285,50.261,51.120,52.086,45.734,P infection group vs health control group=0.000).The levels of ALT,AST,DBIL,TBIL,TBA and ALP in the non-infection group were significantly higher than those in the healthy control group(t non-infection group vs healthy control group=36.319,37.451,47.961,49.212,50.637,41.664,P non-infection group vs healthy control group=0.000).The levels of ALT,AST,DBIL,TBIL,TBA and ALP in children with single virus infection were significantly lower than those in children with complex virus infection(tsingle virus infection vs complex virus infection=3.977,2.885,2.713,2.979,2.911,3.002,P single virus infection vs complex virus infection=0.000,0.005,0.008,0.004,0.004,0.003).ROC curve analysis showed that ALT,AST,DBIL,TBIL,TBA and ALP all could be used to predict virus infection(P<0.05).Conclusion Hepatitis associated virus infection can aggravate liver injury in neonates with hepatitis.Attention should be paid to compound virus infection in clinical diagnosis and treatment,

关 键 词：新生儿肝炎 肝炎相关病毒 巨细胞病毒 肝功能 

分 类 号：R575.1[医药卫生—消化系统]