深圳地区幽门螺旋杆菌感染及抗生素耐药情况分析  

Helicobacter Pylori Infection and Antibiotic Resistance in Shenzhen

作　　者：关幸求[1] 沙菲菲 舒晴[2] GUAN Xing-qiu;SHA Fei-fei;SHU Qing(Department of Digestive,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China;Department of Digestive,the First Affiliated Hospital of Shenzhen University,Shenzhen 518035,Guangdong Province,China)

机构地区：[1]北京大学深圳医院消化内科,广东深圳518036 [2]深圳大学第一附属医院消化内科,广东深圳518035

出　　处：《罕少疾病杂志》2022年第8期103-105,112,共4页Journal of Rare and Uncommon Diseases

摘　　要：目的研究和分析深圳地区幽门螺旋杆菌(Hp)感染现状、抗生素耐药情况及影响因素。方法选取2019年6月至2020年3月于北京大学深圳医院及深圳市第二人民医院行胃镜检查的患者,取胃粘膜组织行幽门螺旋杆菌培养、测定及药敏检测。结果221名患者中Hp感染率为37.6%,不同性别及年龄段间差异均无统计学意义;不同性别、年龄段间Hp单药耐药率及总体耐药情况差异无统计学意义;Hp对抗生素耐药率不同,甲硝唑耐药率最高为92.8%,其次耐药率较高的有克拉霉素53.0%、左氧氟沙星33.7%;Hp抗生素单一耐药率为36.1%,双重耐药率为26.5%,多重耐药率为31.3%。结论深圳地区Hp感染率较既往有降低,但对甲硝唑、克拉霉素、左氧氟沙星的抗生素耐药率呈现上升趋势。Objective To determine the infection situation,antibiotic resistance patterns and influence factors of Helicobacter pylori in Shenzhen.Methods Gastric mucosa tissues were collected from patients with endoscopy in Peking University Shenzhen Hospital and Shenzhen Second People’s Hospital during 2019-06 to 2020-03.Hp was isolated from tissues and,if positive,detected the antibiotic resistance.Results The Hp infection rate was 37.6%in 221 patients,but with no difference between male and female or various ages.The antibiotic resistance rates of Hp were different:the highest rate was 92.8%in metronidazole,followed by 53.0%in clarithromycin,and 33.7%in levofloxacin.The rates of single antibiotics resistance,double resistance and multiple resistance of Hp were 36.1%,26.5%and 31.3%.The resistance rates in single antibiotics or resistance patterns of Hp had no difference between male and female or various ages.Conclusion The Hp infection rate in Shenzhen is lower than before,however,the resistance rates of metronidazole,clarithromycin and levofloxacin are higher.

关 键 词：深圳地区 幽门螺旋杆菌 耐药 

分 类 号：R573.9[医药卫生—消化系统]