OCTA与FFA对中心性浆液性脉络膜视网膜病变并发脉络膜新生血管诊断价值的Meta分析  

Diagnostic value of OCTA and FFA in central serous chorioretinopathy complicated with choroidal neovascularization:a meta-analysis

作　　者：陈君 贾晨 于旭辉[1] Chen Jun;Jia Chen;Yu Xuhui(Department of Ophthalmology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Ophthalmology,Dalian Municipal Central Hospital,Dalian 116033,China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科医院,哈尔滨150001 [2]大连市中心医院眼科,大连116033

出　　处：《中华实验眼科杂志》2022年第7期639-644,共6页Chinese Journal Of Experimental Ophthalmology

摘　　要：目的系统评价光相干断层扫描血管成像(OCTA)与荧光素眼底血管造影(FFA)对中心性浆液性脉络膜视网膜病变(CSC)并发脉络膜新生血管(CNV)的诊断价值。方法检索1991年1月至2020年3月PubMed、Cochrane图书馆、Web of Science、Embase、中国知网、维普数据库及万方数据库以CSC确诊患者作为研究对象,以OCTA和FFA检测CNV为主要分析因素的研究文献。根据纳入和排除标准筛选出符合要求的文献,采用澳大利亚JBI工具对纳入文献进行质量评价。使用Review Manager 5.3软件进行Meta分析,评估OCTA与FFA对CSC患者并发CNV的检出情况,并对年龄、样本总量等进行亚组分析。结果共纳入9篇文献,包括总样本量306例374眼。9篇文献中8篇文献质量评分>14分。OCTA对CSC中CNV的检出率优于FFA[比值比(OR)=3.99,95%可信区间(CI)∶1.44~11.07,P<0.001]。亚组分析结果显示,样本量>40的研究不存在异质性(I^(2)=49%,P=0.14),提示各研究样本纳入总数可能是异质性的来源。漏斗图结果显示文献存在发表偏倚。结论OCTA对CSC并发CNV的检出率高于FFA,其可作为CSC并发CNV的一种常规诊断方法。Objective To systematically evaluate the diagnostic value of optical coherence tomography angiography(OCTA)and fluorescein fundus angiography(FFA)for choroidal neovascularization(CNV)in central serous chorioretinopathy(CSC).Methods PubMed,Cochrane Library,Web of Science,Embase,China National Knowledge Internet(CNKI),VIP database and Wanfang Database were searched for literature published from January 1991 to March 2020 with CSC patients as subjects and OCTA and FFA as diagnostic methods of CNV.The quality of the included literature was evaluated with Australian JBI tool.A meta-analysis was performed using Review Manager 5.3 software.The source of heterogeneity was identified by age and total number of samples subgroup analysis.Results Nine studies with a total sample size of 374 eyes were enrolled.The quality score of 8 studies was greater than 14.The detection rate of CNV in CSC by OCTA was higher than that by FFA[odds ratio(OR)=3.99,95%confidence interval(CI):1.44-11.07,P<0.001].Studies with sample size>40 showed no heterogeneity(I^(2)=49%,P=0.14),suggesting that sample size might be a source of heterogeneity.Publication bias was found by funnel plot.Conclusions OCTA has a higher detection rate of CNV secondary to CSC than FFA,and it can be used as a routine inspection method.

关 键 词：脉络膜新生血管 中心性浆液性脉络膜视网膜病变 光相干断层扫描血管成像 荧光素眼底血管造影 META分析 

分 类 号：R773.4[医药卫生—眼科]