Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma-a translational model  

作　　者：Matias Tellado Sebastian Michinski Joseph Impellizeri Guillermo Marshall Emanuela Signori Felipe Maglietti 

机构地区：[1]VetOncologia,Vet Cancer Clinic,Ciudad de Buenos Aires C1408,Argentina [2]Instituto de Fisica del Plasma,Departamento de Fisica,Facultad de Ciencias Exactas y Naturales,Universidad de Buenos Aires-CONICET,Ciudad de Buenos Aires C1428,Argentina [3]Veterinary Oncology Services,PLLC New York,NY 10065,USA [4]Laboratory of Molecular Pathology and Experimental Oncology,Institute of Translational Pharmacology,CNR,Rome 00133,Italy [5]Instituto Universitario del Hospital Italiano-CONICET,Ciudad de Buenos Aires C1199,Argentina.

出　　处：《Cancer Drug Resistance》2022年第3期595-611,共17页癌症耐药（英文）

基　　金：supported by grants from CONICET,www.conicet.gov.ar,(PIP 379/2012/2016 and STAN 534/12);CNR(CNR Project DSB.AD007.257AD007.072);Universidad de Buenos Aires,www.uba.ar,(UBACyT 2014/2017).

摘　　要：Aim:Cutaneous squamous cell carcinoma(cSCC)is a common disease in patients exposed to UV-light and human papillomavirus.Electrochemotherapy,a well-established treatment modality with minimum side effects in human and veterinary medicine,circumvents chemoresistance to bleomycin by the use of electric fields.However,patients are sensitive to the trauma produced by the insertion of the needles that lengthen recovery times,particularly cats with nasal planum cSCC.To address this matter,we developed thin-needles electrodes.Methods:Thin-needles electrodes developed using computer simulations and plant tissue models were compared to standard electrodes.A prospective non-randomized study recruiting 52 feline patients with nasal planum cSCC was performed.Local response,anorexia,and overall survival were evaluated.Results:Computer simulations and plant model experiments showed satisfactory results with both electrodes.The patients treated with the thin-needle electrode obtained similar local response rates compared to the standard group,OR 97.3%vs.80%,respectively(P<0.067).Most patients in the thin-needle group resumed eating in less than 48 h,as the anorexia was significantly lower(P<0.0001).Using the standard electrode,most patients took 3 to 5 days to resume normal feeding.The electric current circulating in the standard electrode was 44% higher,contributing to a longer duration of anorexia due to tissue damage.The overall survival in both groups was similar.Conclusion:Electrochemotherapy using thin-needle electrodes provides equivalent local response rates and overall survival compared with standard electrodes but significantly reduced return to appetite after the treatment.These results may be useful in the development of new electrodes for human patients.

关 键 词：Cancer SCC NOSE cat ELECTROPORATION ECT tumor cSCC 

分 类 号：R73[医药卫生—肿瘤]