T细胞在系统性硬化症的作用  

Role of T cell in pathogenesis of systemic sclerosis

作　　者：丁汀汀 于震 梁钰颖 温鸿雁[1] DING Ting-ting;YU Zhen;LIANG Yu-ying;WEN Hong-yan(Department of Rheumatology and Immunology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院风湿免疫科,太原030001

出　　处：《中华临床免疫和变态反应杂志》2022年第2期194-199,共6页Chinese Journal of Allergy & Clinical Immunology

基　　金：山西医科大学第二医院青年基金(201902-6)。

摘　　要：系统性硬化症(systemic sclerosis,SSc)是一种病因不明的慢性自身免疫性疾病,以进行性的皮肤及内脏纤维化、微血管系统改变和多种免疫异常为特征,最终导致组织和器官萎缩,预后不良。随着人们对自身免疫性疾病发生发展分子机制的认识,T淋巴细胞介导的异常免疫反应在SSc中的作用已被发现和证实。本文回顾近期文献,综述T细胞亚群及其介导的免疫反应在SSc中对炎症和纤维化的潜在作用。Systemic sclerosis(SSc)is a chronic autoimmune disease of unknown etiology,characterized by progressive cutaneous and visceral fibrosis,changes in the microvascular system,multiple immune abnormalities,ultimately tissue and organ atrophy,and a poor prognosis.With the understanding of the molecular mechanisms underlying the development of autoimmune diseases,the role of T lymphocytes mediated abnormal immune response in SSc has been identified and confirmed.We reviewed the recent literature and summarized the potential role of T cell subsets and immune response in SSc in relation to inflammation and fibrosis.

关 键 词：系统性硬化症 CD4^(+)T淋巴细胞 CD8^(+)T淋巴细胞 

分 类 号：R73[医药卫生—肿瘤]