The influence of nanotopography on cell behaviour through interactions with the extracellular matrix-A review  

作　　者：Jiajun Luo Matthew Walker Yinbo Xiao Hannah Donnelly Matthew J.Dalby Manuel Salmeron-Sanchez 

机构地区：[1]Centre for the Cellular Microenvironment,University of Glasgow,Glasgow,G128LT,UK

出　　处：《Bioactive Materials》2022年第9期145-159,共15页生物活性材料（英文）

基　　金：support from the Leverhulme Trust through grant RPG-2019-252 and the Engineering and Physical Sciences Research Council(EPSRC)grant EP/P001114/1.

摘　　要：Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions.The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours,such as determination of integrin ligation and interaction with growth factors.These interactions with the extracellular matrix regulate downstream mechanotransductive pathways,such as rearrangements in the cytoskeleton and activation of signal cascades.Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and,therefore,subsequent cell responses.In this review,we first discuss the interactive mechanisms of protein physical adsorption on nanotopography.Secondly,we summarise advances in creating nanotopographical features to instruct desired cell behaviours.Lastly,we focus on the cellular mechanotransductive pathways initiated by nanotopography.This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.

关 键 词：NANOTOPOGRAPHY Cell-material interaction Protein adsorption BIOMATERIALS 

分 类 号：R318.08[医药卫生—生物医学工程]